{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":17,"n_cols":5,"rows_kept":17,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[5,2,5,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[12,2,12,3],[13,2,13,3],[16,2,16,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910533954403321"]
[null,null,"Autore",null,"El-Kattan Ayman F."]
[null,null,"Titolo",null,"Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, New Jersey : , : Wiley Blackwell, , 2017"]
[{"$nulls":4},"©2017"]
[null,null,"ISBN",null,"1-118-91693-X"]
[{"$nulls":4},"1-118-91694-8"]
[{"$nulls":4},"1-118-91692-1"]
[null,null,"Descrizione fisica",null,"1 online resource (455 pages) : illustrations"]
[null,null,"Collana",null,"Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods"]
[null,null,"Disciplina",null,"615.1/9"]
[null,null,"Soggetti",null,"Dental pharmacology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective."]