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The Role of Extracellular Matrix in Cancer Development and Progression



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Autore: Tzanakakis George Visualizza persona
Titolo: The Role of Extracellular Matrix in Cancer Development and Progression Visualizza cluster
Pubblicazione: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
Descrizione fisica: 1 electronic resource (182 p.)
Soggetto topico: Research & information: general
Soggetto non controllato: elastin
ribosomal protein SA
tongue carcinoma
MMP-2
EGCG
pancreatic ductal adenocarcinoma
syndecans
proteoglycans
tumor progression
angiogenesis
syndecan-4
heparan sulfate
cancer
prognosis
biomarker
signal transduction
proteoglycan
metastasis
extracellular matrix
fibrosis
immune cell modulation
neutrophils
neutrophil extracellular trap
macrophages
BCC
MMP
TIMP
invasion
lumican
cancer cell growth
motility
hyaluronan
RHAMM
CD44
wound repair
breast cancer
malignant pleural mesothelioma
pleural effusion
extracellular vesicles
biomarkers
sulfated hyaluronan
estrogen receptors
epithelial-to-mesenchymal transition
matrix metalloproteinases
Persona (resp. second.): NikitovicDragana
TzanakakisGeorge
Sommario/riassunto: The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.
Titolo autorizzato: The Role of Extracellular Matrix in Cancer Development and Progression  Visualizza cluster
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910566470803321
Lo trovi qui: Univ. Federico II
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