04164nam 2200877z- 450 991056647080332120231214132948.0(CKB)5680000000037672(oapen)https://directory.doabooks.org/handle/20.500.12854/81159(EXLCZ)99568000000003767220202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Role of Extracellular Matrix in Cancer Development and ProgressionBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (182 p.)3-0365-3405-9 3-0365-3406-7 The extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research.Research & information: generalbicsscelastinribosomal protein SAtongue carcinomaMMP-2EGCGpancreatic ductal adenocarcinomasyndecansproteoglycanstumor progressionangiogenesissyndecan-4heparan sulfatecancerprognosisbiomarkersignal transductionproteoglycanmetastasisextracellular matrixfibrosisimmune cell modulationneutrophilsneutrophil extracellular trapmacrophagesBCCMMPTIMPinvasionlumicancancer cell growthmotilityhyaluronanRHAMMCD44wound repairbreast cancermalignant pleural mesotheliomapleural effusionextracellular vesiclesbiomarkerssulfated hyaluronanestrogen receptorsepithelial-to-mesenchymal transitionmatrix metalloproteinasesResearch & information: generalTzanakakis Georgeedt1326252Nikitovic DraganaedtTzanakakis GeorgeothNikitovic DraganaothBOOK9910566470803321The Role of Extracellular Matrix in Cancer Development and Progression3037218UNINA