LEADER 04205nam 2200901z- 450 001 9910566470803321 005 20220506 035 $a(CKB)5680000000037672 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81159 035 $a(oapen)doab81159 035 $a(EXLCZ)995680000000037672 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aThe Role of Extracellular Matrix in Cancer Development and Progression 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (182 p.) 311 08$a3-0365-3405-9 311 08$a3-0365-3406-7 330 $aThe extracellular matrix (ECM) scaffold, which surrounds and supports the cells in tissues, consists of fibrillar proteins, proteoglycans, glycosaminoglycans, signaling molecules, and enzymes involved in its remodeling. The stages of cancer progression, e.g., local invasion, intravasation, extravasation, distant invasion and immunosuppression, are obligatorily perpetrated through interactions of these tumor cells with the ECM. Cancer-related ECM changes can be exploited for the evaluation of disease progression, anticancer therapy development, and monitoring of therapy response. Thus, in breast cancer, hyaluronan-mediated wound repair mechanisms are hijacked to promote tumor development. Altered mechanical properties of the pancreatic cancer ECM are immunosuppressive and prevent the penetration of cytotoxic chemotherapy agents. The expression of the proteoglycan syndecan-4 is modulated by anticancer drugs, suggesting its potential druggabilty capacity. Another proteoglycan, lumican, is proposed as a cancer prognosis marker, chemoresistance regulator, and cancer therapy target. Due to their remodeling properties, the MMPs are vital mediators and important therapeutic targets. Treatment of breast cancer cells with sulfated hyaluronan has been shown to attenuate tumor cell growth, migration, and invasion. Extracellular vesicles (EVs), comprising exosomes, microvesicles, and apoptotic bodies, are released by all cells into the ECM and body fluids and can be utilized as diagnostic markers in malignant pleural mesothelioma. These exciting developments encourage tumor biology scientists for further creative research. 606 $aResearch and information: general$2bicssc 610 $aangiogenesis 610 $aBCC 610 $abiomarker 610 $abiomarkers 610 $abreast cancer 610 $acancer 610 $acancer cell growth 610 $aCD44 610 $aEGCG 610 $aelastin 610 $aepithelial-to-mesenchymal transition 610 $aestrogen receptors 610 $aextracellular matrix 610 $aextracellular vesicles 610 $afibrosis 610 $aheparan sulfate 610 $ahyaluronan 610 $aimmune cell modulation 610 $ainvasion 610 $alumican 610 $amacrophages 610 $amalignant pleural mesothelioma 610 $amatrix metalloproteinases 610 $ametastasis 610 $aMMP 610 $aMMP-2 610 $amotility 610 $an/a 610 $aneutrophil extracellular trap 610 $aneutrophils 610 $apancreatic ductal adenocarcinoma 610 $apleural effusion 610 $aprognosis 610 $aproteoglycan 610 $aproteoglycans 610 $aRHAMM 610 $aribosomal protein SA 610 $asignal transduction 610 $asulfated hyaluronan 610 $asyndecan-4 610 $asyndecans 610 $aTIMP 610 $atongue carcinoma 610 $atumor progression 610 $awound repair 615 7$aResearch and information: general 700 $aTzanakakis$b George$4edt$01326252 702 $aNikitovic$b Dragana$4edt 702 $aTzanakakis$b George$4oth 702 $aNikitovic$b Dragana$4oth 906 $aBOOK 912 $a9910566470803321 996 $aThe Role of Extracellular Matrix in Cancer Development and Progression$93037218 997 $aUNINA