Biologic markers in reproductive toxicology / / Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council

• Pubblicazione: Washington, D.C. : , : National Academy Press, , 1989
• Descrizione fisica: 1 online resource (xxi, 395 pages) : illustrations
• Disciplina: 616.6/507
• Soggetto topico: Reproductive toxicology; Biochemical markers
• Soggetto non controllato: Cytology; Science
• Note generali: Includes index.
• Nota di bibliografia: Includes bibliography (p. 319-372) and index.
• Nota di contenuto: Executive summary -- Report of the Oversight Committee. I. Biologic markers in male reproductive and gametic genetic toxicology. Introduction -- Clinical evaluation of male infertility -- Biologic markers of testicular function -- Biologic markers of epididymal structure and function -- Biologic markers of accessory sex organ structure and function -- Biologic markers of human male reproductive health and physiologic damage -- Assessing transmitted mutations in mice -- Markers for measuring germinal genetic toxicity and heritable mutations in people -- Conclusions and recommendations. II. Biologic markers in female reproductive toxicology. Introduction -- Biologic markers of genetic damage in females -- Biologic markers of reproductive development and aging -- Biologic markers of nonconceptive menstrual cycles -- Developing assays of biologic markers for epidemiologic studies: experience with a marker of pregnancy and early loss -- Conclusions and recommendations. III. Biologic markers of toxicity during pregnancy. Introduction -- Molecular biology: developing DNA markers of genotoxic effects -- Reproductive immunology: biologic markers of compromised pregnancies -- Cell biology: identifying biologic markers expressed during early pregnancy -- Physiologic assessment of fetal compromise -- Conclusions and Recommendations. IV. Biologic Markers in Neurodevelopmental Toxicology. Introduction -- Developmental neurobiology of the central nervous system -- Morphologic, neurochemical, and behavioral responses to toxic agents -- Methodologic issues of extrapolation from animal studies to human toxicant exposure -- Lead as a paradigm for the study of neurodevelopmental toxicology -- Conclusions and recommendations -- Appendix: Assessing the validity of biologic markers: alpha-fetoprotein -- References -- Biographies -- Index.
• Sommario/riassunto: Examines the potential use of these markers in environmental health studies, and clarifies definitions, underlying concepts, and possible applications. Acidic paper. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com).
• Titolo autorizzato: Biologic markers in reproductive toxicology
• ISBN: 1-280-21474-0; 9786610214747; 0-309-56814-5; 0-585-14391-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910778710203321
• Lo trovi qui: Univ. Federico II