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Record Nr. |
UNINA9910778710203321 |
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Titolo |
Biologic markers in reproductive toxicology / / Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
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Pubbl/distr/stampa |
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Washington, D.C. : , : National Academy Press, , 1989 |
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ISBN |
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1-280-21474-0 |
9786610214747 |
0-309-56814-5 |
0-585-14391-9 |
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Descrizione fisica |
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1 online resource (xxi, 395 pages) : illustrations |
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Disciplina |
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Soggetti |
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Reproductive toxicology |
Biochemical markers |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Nota di bibliografia |
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Includes bibliography (p. 319-372) and index. |
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Nota di contenuto |
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Executive summary -- Report of the Oversight Committee. I. Biologic markers in male reproductive and gametic genetic toxicology. Introduction -- Clinical evaluation of male infertility -- Biologic markers of testicular function -- Biologic markers of epididymal structure and function -- Biologic markers of accessory sex organ structure and function -- Biologic markers of human male reproductive health and physiologic damage -- Assessing transmitted mutations in mice -- Markers for measuring germinal genetic toxicity and heritable mutations in people -- Conclusions and recommendations. II. Biologic markers in female reproductive toxicology. Introduction -- Biologic markers of genetic damage in females -- Biologic markers of reproductive development and aging -- Biologic markers of nonconceptive menstrual cycles -- Developing assays of biologic markers for epidemiologic studies: experience with a marker of pregnancy and early loss -- Conclusions and recommendations. III. Biologic markers of toxicity during pregnancy. Introduction -- Molecular biology: developing DNA markers of genotoxic effects -- |
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Reproductive immunology: biologic markers of compromised pregnancies -- Cell biology: identifying biologic markers expressed during early pregnancy -- Physiologic assessment of fetal compromise -- Conclusions and Recommendations. IV. Biologic Markers in Neurodevelopmental Toxicology. Introduction -- Developmental neurobiology of the central nervous system -- Morphologic, neurochemical, and behavioral responses to toxic agents -- Methodologic issues of extrapolation from animal studies to human toxicant exposure -- Lead as a paradigm for the study of neurodevelopmental toxicology -- Conclusions and recommendations -- Appendix: Assessing the validity of biologic markers: alpha-fetoprotein -- References -- Biographies -- Index. |
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Sommario/riassunto |
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Examines the potential use of these markers in environmental health studies, and clarifies definitions, underlying concepts, and possible applications. Acidic paper. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com). |
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