LEADER 04156nam 2200625Ia 450 001 9910778710203321 005 20231009234339.0 010 $a1-280-21474-0 010 $a9786610214747 010 $a0-309-56814-5 010 $a0-585-14391-9 035 $a(CKB)111004366658452 035 $a(OCoLC)726823183 035 $a(CaPaEBR)ebrary10071414 035 $a(MiAaPQ)EBC3377387 035 $a(Au-PeEL)EBL3377387 035 $a(CaPaEBR)ebr10071414 035 $a(CaONFJC)MIL21474 035 $a(OCoLC)923270222 035 $a(NjHacI)99111004366658452 035 $a(BIP)000162739 035 $a(EXLCZ)99111004366658452 100 $a19901022d1989 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBiologic markers in reproductive toxicology /$fSubcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council 210 1$aWashington, D.C. :$cNational Academy Press,$d1989. 215 $a1 online resource (xxi, 395 pages) $cillustrations 300 $aIncludes index. 311 0 $a0-309-03979-7 320 $aIncludes bibliography (p. 319-372) and index. 327 $aExecutive summary -- Report of the Oversight Committee. I. Biologic markers in male reproductive and gametic genetic toxicology. Introduction -- Clinical evaluation of male infertility -- Biologic markers of testicular function -- Biologic markers of epididymal structure and function -- Biologic markers of accessory sex organ structure and function -- Biologic markers of human male reproductive health and physiologic damage -- Assessing transmitted mutations in mice -- Markers for measuring germinal genetic toxicity and heritable mutations in people -- Conclusions and recommendations. II. Biologic markers in female reproductive toxicology. Introduction -- Biologic markers of genetic damage in females -- Biologic markers of reproductive development and aging -- Biologic markers of nonconceptive menstrual cycles -- Developing assays of biologic markers for epidemiologic studies: experience with a marker of pregnancy and early loss -- Conclusions and recommendations. III. Biologic markers of toxicity during pregnancy. Introduction -- Molecular biology: developing DNA markers of genotoxic effects -- Reproductive immunology: biologic markers of compromised pregnancies -- Cell biology: identifying biologic markers expressed during early pregnancy -- Physiologic assessment of fetal compromise -- Conclusions and Recommendations. IV. Biologic Markers in Neurodevelopmental Toxicology. Introduction -- Developmental neurobiology of the central nervous system -- Morphologic, neurochemical, and behavioral responses to toxic agents -- Methodologic issues of extrapolation from animal studies to human toxicant exposure -- Lead as a paradigm for the study of neurodevelopmental toxicology -- Conclusions and recommendations -- Appendix: Assessing the validity of biologic markers: alpha-fetoprotein -- References -- Biographies -- Index. 330 $aExamines the potential use of these markers in environmental health studies, and clarifies definitions, underlying concepts, and possible applications. Acidic paper. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com). 606 $aReproductive toxicology 606 $aBiochemical markers 610 $aCytology 610 $aScience 615 0$aReproductive toxicology. 615 0$aBiochemical markers. 676 $a616.6/507 712 02$aDivision on Earth and Life Studies, 712 02$aCommission on Life Sciences, 712 02$aBoard on Environmental Studies and Toxicology, 712 02$aCommittee on Biologic Markers, 712 02$aSubcommittee on Reproductive and Neurodevelopmental Toxicology, 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910778710203321 996 $aBiologic markers in reproductive toxicology$93731902 997 $aUNINA