Thymic Development and Selection of T Lymphocytes [[electronic resource] /] / edited by Thomas Boehm, Yousuke Takahama
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| Titolo: |
Thymic Development and Selection of T Lymphocytes [[electronic resource] /] / edited by Thomas Boehm, Yousuke Takahama
|
| Pubblicazione: | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Edizione: | 1st ed. 2014. |
| Descrizione fisica: | 1 online resource (134 p.) |
| Disciplina: | 611.01816 |
| Soggetto topico: | Immunology |
| Human physiology | |
| Cytogenetics | |
| Human Physiology | |
| Persona (resp. second.): | BoehmThomas |
| TakahamaYousuke | |
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes. |
| Sommario/riassunto: | The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity. |
| Titolo autorizzato: | Thymic Development and Selection of T Lymphocytes |
| ISBN: | 3-642-40252-6 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910298311503321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Current Topics in Microbiology and Immunology, . 0070-217X ; ; 373