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010   $a3-642-40252-6
024 7 $a10.1007/978-3-642-40252-4
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035   $a(DE-He213)978-3-642-40252-4
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100   $a20131106d2014      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aThymic Development and Selection of T Lymphocytes /$fedited by Thomas Boehm, Yousuke Takahama
205   $a1st ed. 2014.
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2014.
215   $a1 online resource (134 p.)
225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v373
300   $aDescription based upon print version of record.
311   $a3-642-40251-8 
320   $aIncludes bibliographical references and index.
327   $aDevelopment and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-  Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
330   $aThe thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
410  0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v373
606   $aImmunology
606   $aHuman physiology
606   $aCytogenetics
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004
606   $aCytogenetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12040
615  0$aImmunology.
615  0$aHuman physiology.
615  0$aCytogenetics.
615 14$aImmunology.
615 24$aHuman Physiology.
615 24$aCytogenetics.
676   $a611.01816
702   $aBoehm$b Thomas$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aTakahama$b Yousuke$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298311503321
996   $aThymic Development and Selection of T Lymphocytes$92498382
997   $aUNINA