03441nam 22006495 450 991029831150332120200701085251.03-642-40252-610.1007/978-3-642-40252-4(CKB)3710000000058071(EBL)1593173(OCoLC)865555648(SSID)ssj0001066562(PQKBManifestationID)11691127(PQKBTitleCode)TC0001066562(PQKBWorkID)11072242(PQKB)10318755(MiAaPQ)EBC1593173(DE-He213)978-3-642-40252-4(PPN)176114416(EXLCZ)99371000000005807120131106d2014 u| 0engur|n|---|||||txtccrThymic Development and Selection of T Lymphocytes[electronic resource] /edited by Thomas Boehm, Yousuke Takahama1st ed. 2014.Berlin, Heidelberg :Springer Berlin Heidelberg :Imprint: Springer,2014.1 online resource (134 p.)Current Topics in Microbiology and Immunology,0070-217X ;373Description based upon print version of record.3-642-40251-8 Includes bibliographical references and index.Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-  Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.Current Topics in Microbiology and Immunology,0070-217X ;373ImmunologyHuman physiologyCytogeneticsImmunologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B14000Human Physiologyhttps://scigraph.springernature.com/ontologies/product-market-codes/B13004Cytogeneticshttps://scigraph.springernature.com/ontologies/product-market-codes/B12040Immunology.Human physiology.Cytogenetics.Immunology.Human Physiology.Cytogenetics.611.01816Boehm Thomasedthttp://id.loc.gov/vocabulary/relators/edtTakahama Yousukeedthttp://id.loc.gov/vocabulary/relators/edtBOOK9910298311503321Thymic Development and Selection of T Lymphocytes2498382UNINA