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Advances in Mechanisms of Renal Fibrosis



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Autore: David J. Nikolic-Paterson Visualizza persona
Titolo: Advances in Mechanisms of Renal Fibrosis Visualizza cluster
Pubblicazione: Frontiers Media SA, 2018
Descrizione fisica: 1 electronic resource (84 p.)
Soggetto non controllato: TGF-beta
fibroblast
JNK
miRNA
Smad
non-classical RAS
BMP7
HDAC
HIPK2
Persona (resp. second.): Hui Y. Lan
Sommario/riassunto: Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
Titolo autorizzato: Advances in Mechanisms of Renal Fibrosis  Visualizza cluster
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910346754103321
Lo trovi qui: Univ. Federico II
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