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Autore: | David J. Nikolic-Paterson |
Titolo: | Advances in Mechanisms of Renal Fibrosis |
Pubblicazione: | Frontiers Media SA, 2018 |
Descrizione fisica: | 1 electronic resource (84 p.) |
Soggetto non controllato: | TGF-beta |
fibroblast | |
JNK | |
miRNA | |
Smad | |
non-classical RAS | |
BMP7 | |
HDAC | |
HIPK2 | |
Persona (resp. second.): | Hui Y. Lan |
Sommario/riassunto: | Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis. |
Titolo autorizzato: | Advances in Mechanisms of Renal Fibrosis |
Formato: | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910346754103321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |