Drug efficacy, safety, and biologics discovery : emerging technologies and tools / / [edited by] Sean Ekins, Jinghai J. Xu

• Pubblicazione: Hoboken, N.J. : , : John Wiley & Sons, , 2009; ©2009
• Descrizione fisica: 1 online resource (xvi, 408 pages, 16 unnumbered pages of plates) : illustrations (some color)
• Disciplina: 615/.19
• Soggetto topico: Drug development - Technological innovations; Pharmaceutical technology; Biological products
• Altri autori: EkinsSean XuJinghai J
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Focus on the fundamentals : toward better therapeutic index prediction / Jinghai J. Xu and Li J. Yu -- High-throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. Alexopoulos, Julio Saez Rodriguez, and Christopher W. Espelin -- Cellular systems biology applied to preclinical safety testing : a case study of CellCiphr profiling / Lawrence Vernetti ... [et al.] -- Systems pharmacology, biomarkers, and biomolecular networks / Aram S. Adourian ... [et al.] -- Zebrafish models for human diseases and drug discovery / Hanbing Zhong, Ning-Ai Liu, and Shuo Lin -- Toxicity pathways and models : mining for potential side effects / Sean Ekins and Josef Scheiber -- Computational systems biology modeling of dosimetry and cellular response pathways / Qiang Zhang ... [et al.] -- ; Stem cell technology for embryotoxicity, cardiotoxicity, and hepatotoxicity evaluation / Julio C. Davila ... [et al.] -- Telemetry technology for preclinical drug discovery and development / Yi Yang --Nanotechnology to improve oral drug delivery / Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji -- Functional glycomics and the future of glycomic drugs / Ram Sasisekharan and Karthik Viswanathan -- Modeling efficacy and safety of engineered biologics / Jeffrey R. Chabot and Bruce Gomes -- Regulation of gene expression by small, non-coding RNAS : practical applications / Roman Herrara and Eric Tien -- Future perspectives of biological engineering in pharmaceutical research : the paradigm of modeling, mining, manipulation, and measurements / Jinghai J. Xu ... [et al.].
• Sommario/riassunto: This book covers key emerging technologies - detailed under About the Topic - in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
• Titolo autorizzato: Drug efficacy, safety, and biologics discovery
• ISBN: 1-282-26780-9; 9786612267802; 0-470-43181-4; 0-470-43180-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910145817703321
• Lo trovi qui: Univ. Federico II
• Serie: Wiley series on technologies for the pharmaceutical industry.