LEADER 04336oam 22006614a 450 001 9910145817703321 005 20231127162541.0 010 $a1-282-26780-9 010 $a9786612267802 010 $a0-470-43181-4 010 $a0-470-43180-6 035 $a(CKB)1000000000715847 035 $a(EBL)416167 035 $a(OCoLC)476247145 035 $a(SSID)ssj0000294348 035 $a(PQKBManifestationID)11206504 035 $a(PQKBTitleCode)TC0000294348 035 $a(PQKBWorkID)10311926 035 $a(PQKB)11187494 035 $a(MiAaPQ)EBC416167 035 $a(Au-PeEL)EBL416167 035 $a(CaPaEBR)ebr10296350 035 $a(CaONFJC)MIL226780 035 $a(PPN)161432808 035 $a(EXLCZ)991000000000715847 100 $a20080814h20092009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDrug efficacy, safety, and biologics discovery $eemerging technologies and tools /$f[edited by] Sean Ekins, Jinghai J. Xu 210 1$aHoboken, N.J. :$cJohn Wiley & Sons,$d2009. 210 4$dİ2009 215 $a1 online resource (xvi, 408 pages, 16 unnumbered pages of plates) $cillustrations (some color) 225 1 $aWiley series on technologies for the pharmaceutical industry 311 0 $a0-470-22555-6 320 $aIncludes bibliographical references and index. 327 $aFocus on the fundamentals : toward better therapeutic index prediction / Jinghai J. Xu and Li J. Yu -- High-throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. Alexopoulos, Julio Saez Rodriguez, and Christopher W. Espelin -- Cellular systems biology applied to preclinical safety testing : a case study of CellCiphr profiling / Lawrence Vernetti ... [et al.] -- Systems pharmacology, biomarkers, and biomolecular networks / Aram S. Adourian ... [et al.] -- Zebrafish models for human diseases and drug discovery / Hanbing Zhong, Ning-Ai Liu, and Shuo Lin -- Toxicity pathways and models : mining for potential side effects / Sean Ekins and Josef Scheiber -- Computational systems biology modeling of dosimetry and cellular response pathways / Qiang Zhang ... [et al.] -- 327 $aStem cell technology for embryotoxicity, cardiotoxicity, and hepatotoxicity evaluation / Julio C. Davila ... [et al.] -- Telemetry technology for preclinical drug discovery and development / Yi Yang --Nanotechnology to improve oral drug delivery / Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji -- Functional glycomics and the future of glycomic drugs / Ram Sasisekharan and Karthik Viswanathan -- Modeling efficacy and safety of engineered biologics / Jeffrey R. Chabot and Bruce Gomes -- Regulation of gene expression by small, non-coding RNAS : practical applications / Roman Herrara and Eric Tien -- Future perspectives of biological engineering in pharmaceutical research : the paradigm of modeling, mining, manipulation, and measurements / Jinghai J. Xu ... [et al.]. 330 $aThis book covers key emerging technologies - detailed under About the Topic - in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development. 410 0$aWiley series on technologies for the pharmaceutical industry. 606 $aDrug development$xTechnological innovations 606 $aPharmaceutical technology 606 $aBiological products 615 0$aDrug development$xTechnological innovations. 615 0$aPharmaceutical technology. 615 0$aBiological products. 676 $a615/.19 701 $aEkins$b Sean$0927740 701 $aXu$b Jinghai J$0973209 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910145817703321 996 $aDrug efficacy, safety, and biologics discovery$92214172 997 $aUNINA