04336oam 22006614a 450 991014581770332120231127162541.01-282-26780-997866122678020-470-43181-40-470-43180-6(CKB)1000000000715847(EBL)416167(OCoLC)476247145(SSID)ssj0000294348(PQKBManifestationID)11206504(PQKBTitleCode)TC0000294348(PQKBWorkID)10311926(PQKB)11187494(MiAaPQ)EBC416167(Au-PeEL)EBL416167(CaPaEBR)ebr10296350(CaONFJC)MIL226780(PPN)161432808(EXLCZ)99100000000071584720080814h20092009 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierDrug efficacy, safety, and biologics discovery emerging technologies and tools /[edited by] Sean Ekins, Jinghai J. XuHoboken, N.J. :John Wiley & Sons,2009.©20091 online resource (xvi, 408 pages, 16 unnumbered pages of plates) illustrations (some color)Wiley series on technologies for the pharmaceutical industry0-470-22555-6 Includes bibliographical references and index.Focus on the fundamentals : toward better therapeutic index prediction / Jinghai J. Xu and Li J. Yu -- High-throughput protein-based technologies and computational models for drug development, efficacy, and toxicity / Leonidas G. Alexopoulos, Julio Saez Rodriguez, and Christopher W. Espelin -- Cellular systems biology applied to preclinical safety testing : a case study of CellCiphr profiling / Lawrence Vernetti ... [et al.] -- Systems pharmacology, biomarkers, and biomolecular networks / Aram S. Adourian ... [et al.] -- Zebrafish models for human diseases and drug discovery / Hanbing Zhong, Ning-Ai Liu, and Shuo Lin -- Toxicity pathways and models : mining for potential side effects / Sean Ekins and Josef Scheiber -- Computational systems biology modeling of dosimetry and cellular response pathways / Qiang Zhang ... [et al.] --Stem cell technology for embryotoxicity, cardiotoxicity, and hepatotoxicity evaluation / Julio C. Davila ... [et al.] -- Telemetry technology for preclinical drug discovery and development / Yi Yang --Nanotechnology to improve oral drug delivery / Mayank D. Bhavsar, Shardool Jain, and Mansoor M. Amiji -- Functional glycomics and the future of glycomic drugs / Ram Sasisekharan and Karthik Viswanathan -- Modeling efficacy and safety of engineered biologics / Jeffrey R. Chabot and Bruce Gomes -- Regulation of gene expression by small, non-coding RNAS : practical applications / Roman Herrara and Eric Tien -- Future perspectives of biological engineering in pharmaceutical research : the paradigm of modeling, mining, manipulation, and measurements / Jinghai J. Xu ... [et al.].This book covers key emerging technologies - detailed under About the Topic - in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.Wiley series on technologies for the pharmaceutical industry.Drug developmentTechnological innovationsPharmaceutical technologyBiological productsDrug developmentTechnological innovations.Pharmaceutical technology.Biological products.615/.19Ekins Sean927740Xu Jinghai J973209MiAaPQMiAaPQMiAaPQBOOK9910145817703321Drug efficacy, safety, and biologics discovery2214172UNINA