Asymmetric catalysis on industrial scale : challenges, approaches and solutions / / edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel

• Pubblicazione: Weinheim : , : Wiley-VCH, , [2010]; ©2010
• Edizione: 2nd ed.
• Descrizione fisica: 1 online resource (582 p.)
• Disciplina: 547.1395
• Soggetto topico: Enantioselective catalysis; Asymmetric synthesis; Enantioselective catalysis - Industrial applications
• Persona (resp. second.): BlaserH. U.; FederselHans-Jurgen
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Asymmetric Catalysis on Industrial Scale; Contents; List of Contributors; Introduction; Part I New processes for Existing Active Compounds (APIs); 1 Some Recent Examples in Developing Biocatalytic Pharmaceutical Processes; 2 Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals; 3 Chiral Lactones by Asymmetric Hydrogenation - a Step Forward in (+)-Biotin Production; 4 Biocatalytic Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics ; 10 Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in the Pharmaceutical Industry11 The Asymmetric Hydrogenation of Enones - Access to a New L-Menthol Synthesis; 12 Eliminating Barriers in Large-Scale Asymmetric Synthesis; 13 Catalytic Asymmetric Ring Opening: A Transfer from Academia to Industry; 14 Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts; 15 Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis; 16 Scale-Up Studies in Asymmetric Transfer Hydrogenation ; 17 2,2 ,5,5 -Tetramethyl-4,4 -bis(diphenylphoshino)-3,3 -bithiophene: A Very Efficient Chiral Ligand for Ru-Catalyzed Asymmetric Hydrogenations on the Multi-Kilograms Scale18 The Power of Whole-Cell Reaction: Efficient Production of Hydroxyproline, Sugar Nucleotides, Oligosaccharides, and Dipeptides; 19 Enantioselective Ketone Hydrogenation: from Research to Pilot Scale with Industrially Viable Ru-(Phosphine-Oxazoline) Complexes; Part III Processes for New Chemical Entities (NCEs); 20 Enabling Asymmetric Hydrogenation for the Design of Ef.cient Synthesis of Drug Substances ; 21 Scale-up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor22 An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme-Mediated Dynamic Kinetic Resolution; 23 Biocatalytic Routes to the GPIIb/IIIa Antagonist Lotrafiban, SB 214857; 24 Discovery and Development of a Catalytic Asymmetric Conjugate Addition of Ketoesters to Nitroalkenes and Its Use in the Large-Scale Preparation of ABT-546 ; 25 The Kagan Oxidation - Industrial-Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 Antagonists
• Sommario/riassunto: This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the cata
• Titolo autorizzato: Asymmetric catalysis on industrial scale
• ISBN: 1-282-78388-2; 9786612783883; 3-527-64216-1; 3-527-63064-3; 3-527-63063-5
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830875203321
• Lo trovi qui: Univ. Federico II