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[null,"1.","Record Nr.",null,"UNINA9910830875203321"]
[null,null,"Titolo",null,"Asymmetric catalysis on industrial scale : challenges, approaches and solutions / / edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim : , : Wiley-VCH, , [2010]"]
[{"$nulls":4},"©2010"]
[null,null,"ISBN",null,"1-282-78388-2"]
[{"$nulls":4},"9786612783883"]
[{"$nulls":4},"3-527-64216-1"]
[{"$nulls":4},"3-527-63064-3"]
[{"$nulls":4},"3-527-63063-5"]
[null,null,"Edizione",null,"[2nd ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (582 p.)"]
[null,null,"Disciplina",null,"547.1395"]
[null,null,"Soggetti",null,"Enantioselective catalysis"]
[{"$nulls":4},"Asymmetric synthesis"]
[{"$nulls":4},"Enantioselective catalysis - Industrial applications"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Asymmetric Catalysis on Industrial Scale; Contents; List of Contributors; Introduction; Part I New processes for Existing Active Compounds (APIs); 1 Some Recent Examples in Developing Biocatalytic Pharmaceutical Processes; 2 Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals; 3 Chiral Lactones by Asymmetric Hydrogenation - a Step Forward in (+)-Biotin Production; 4 Biocatalytic Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics"]
[{"$nulls":4},"10 Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in the Pharmaceutical Industry11 The Asymmetric Hydrogenation of Enones - Access to a New L-Menthol Synthesis; 12 Eliminating Barriers in Large-Scale Asymmetric Synthesis; 13 Catalytic Asymmetric Ring Opening: A Transfer from Academia to Industry; 14 Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts; 15 Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis; 16 Scale-Up Studies in Asymmetric Transfer Hydrogenation"]
[{"$nulls":4},"17 2,2 ,5,5 -Tetramethyl-4,4 -bis(diphenylphoshino)-3,3 -bithiophene: A Very Efficient Chiral Ligand for Ru-Catalyzed "]
[{"$nulls":4},"Asymmetric Hydrogenations on the Multi-Kilograms Scale18 The Power of Whole-Cell Reaction: Efficient Production of Hydroxyproline, Sugar Nucleotides, Oligosaccharides, and Dipeptides; 19 Enantioselective Ketone Hydrogenation: from Research to Pilot Scale with Industrially Viable Ru-(Phosphine-Oxazoline) Complexes; Part III Processes for New Chemical Entities (NCEs); 20 Enabling Asymmetric Hydrogenation for the Design of Ef.cient Synthesis of Drug Substances"]
[{"$nulls":4},"21 Scale-up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor22 An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme-Mediated Dynamic Kinetic Resolution; 23 Biocatalytic Routes to the GPIIb/IIIa Antagonist Lotrafiban, SB 214857; 24 Discovery and Development of a Catalytic Asymmetric Conjugate Addition of Ketoesters to Nitroalkenes and Its Use in the Large-Scale Preparation of ABT-546"]
[{"$nulls":4},"25 The Kagan Oxidation - Industrial-Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 Antagonists"]
[null,null,null,"Sommario/riassunto","This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the cata"]