LEADER 04788nam 2200661 450 001 9910830875203321 005 20230725023016.0 010 $a1-282-78388-2 010 $a9786612783883 010 $a3-527-64216-1 010 $a3-527-63064-3 010 $a3-527-63063-5 035 $a(CKB)2580000000000349 035 $a(EBL)584979 035 $a(OCoLC)670411404 035 $a(SSID)ssj0000412275 035 $a(PQKBManifestationID)11306239 035 $a(PQKBTitleCode)TC0000412275 035 $a(PQKBWorkID)10366323 035 $a(PQKB)10105242 035 $a(MiAaPQ)EBC584979 035 $a(EXLCZ)992580000000000349 100 $a20110110h20102010 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAsymmetric catalysis on industrial scale $echallenges, approaches and solutions /$fedited by Hans-Ulrich Blaser and Hans-Ju?rgen Federsel 205 $a2nd ed. 210 1$aWeinheim :$cWiley-VCH,$d[2010] 210 4$dİ2010 215 $a1 online resource (582 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32489-5 320 $aIncludes bibliographical references and index. 327 $aAsymmetric Catalysis on Industrial Scale; Contents; List of Contributors; Introduction; Part I New processes for Existing Active Compounds (APIs); 1 Some Recent Examples in Developing Biocatalytic Pharmaceutical Processes; 2 Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals; 3 Chiral Lactones by Asymmetric Hydrogenation - a Step Forward in (+)-Biotin Production; 4 Biocatalytic Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics 327 $a10 Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in the Pharmaceutical Industry11 The Asymmetric Hydrogenation of Enones - Access to a New L-Menthol Synthesis; 12 Eliminating Barriers in Large-Scale Asymmetric Synthesis; 13 Catalytic Asymmetric Ring Opening: A Transfer from Academia to Industry; 14 Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts; 15 Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis; 16 Scale-Up Studies in Asymmetric Transfer Hydrogenation 327 $a17 2,2 ,5,5 -Tetramethyl-4,4 -bis(diphenylphoshino)-3,3 -bithiophene: A Very Efficient Chiral Ligand for Ru-Catalyzed Asymmetric Hydrogenations on the Multi-Kilograms Scale18 The Power of Whole-Cell Reaction: Efficient Production of Hydroxyproline, Sugar Nucleotides, Oligosaccharides, and Dipeptides; 19 Enantioselective Ketone Hydrogenation: from Research to Pilot Scale with Industrially Viable Ru-(Phosphine-Oxazoline) Complexes; Part III Processes for New Chemical Entities (NCEs); 20 Enabling Asymmetric Hydrogenation for the Design of Ef.cient Synthesis of Drug Substances 327 $a21 Scale-up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor22 An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme-Mediated Dynamic Kinetic Resolution; 23 Biocatalytic Routes to the GPIIb/IIIa Antagonist Lotrafiban, SB 214857; 24 Discovery and Development of a Catalytic Asymmetric Conjugate Addition of Ketoesters to Nitroalkenes and Its Use in the Large-Scale Preparation of ABT-546 327 $a25 The Kagan Oxidation - Industrial-Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 Antagonists 330 $aThis second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the cata 606 $aEnantioselective catalysis 606 $aAsymmetric synthesis 606 $aEnantioselective catalysis$xIndustrial applications$vCase studies 615 0$aEnantioselective catalysis. 615 0$aAsymmetric synthesis. 615 0$aEnantioselective catalysis$xIndustrial applications 676 $a547.1395 702 $aBlaser$b H. U. 702 $aFedersel$b Hans-Jurgen 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910830875203321 996 $aAsymmetric catalysis on industrial scale$985703 997 $aUNINA