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Advances in Pharmacokinetics and Pharmacodynamics / / edited by Panos Macheras



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Autore: Macheras Panos Visualizza persona
Titolo: Advances in Pharmacokinetics and Pharmacodynamics / / edited by Panos Macheras Visualizza cluster
Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Edizione: 1st ed. 2023.
Descrizione fisica: 1 online resource (208 pages)
Disciplina: 615.7
Soggetto topico: Drug delivery systems
Drugs—Design
Pharmaceutical chemistry
Metabolism
Pharmacology
Clinical biochemistry
Drug Delivery
Structure-Based Drug Design
Pharmaceutics
Medical Biochemistry
Soggetto non controllato: Therapeutics
Medical
Persona (resp. second.): MacherasPanos
Nota di contenuto: Pharmacokinetics -- Chapter 1: Current status in PBPK modeling -- Chapter 2: Physiologically based biopharmaceutics modeling (PBBM) Application on Food Effect Assessment -- Chapter 3: Physiologically based finite time pharmacokinetic (PBFTPK) models: Inception and development -- Chapter 4: Physiologically based finite time pharmacokinetic (PBFTPK) models: Applications -- Pharmacodynamics -- Chapter 5: Pharmacokinetic – Pharmacodynamic Modelling and Simulation in Clinical Practice and Studies -- Chapter 6: On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body -- Chapter 7: Impact of Clinical Pharmacology on the Modernization of Drug Development and Regulation.
Sommario/riassunto: This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Titolo autorizzato: Advances in Pharmacokinetics and Pharmacodynamics  Visualizza cluster
ISBN: 9783031295416
9783031295409
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910728396903321
Lo trovi qui: Univ. Federico II
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Serie: AAPS Introductions in the Pharmaceutical Sciences, . 2522-8358 ; ; 9