LEADER 04125nam  22007695  450 
001 9910728396903321
005 20251008144934.0
010   $a9783031295416$b(electronic bk.)
010   $z9783031295409
024 7 $a10.1007/978-3-031-29541-6
035   $a(MiAaPQ)EBC30552979
035   $a(Au-PeEL)EBL30552979
035   $a(OCoLC)1380875404
035   $a(DE-He213)978-3-031-29541-6
035   $a(BIP)089067678
035   $a(PPN)270616381
035   $a(CKB)26784778600041
035   $a(EXLCZ)9926784778600041
100   $a20230526d2023      u|         0
101 0 $aeng
135   $aurcnu||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAdvances in Pharmacokinetics and Pharmacodynamics /$fedited by Panos Macheras
205   $a1st ed. 2023.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023.
215   $a1 online resource (208 pages)
225 1 $aAAPS Introductions in the Pharmaceutical Sciences,$x2522-8358 ;$v9
311 08$aPrint version: Macheras, Panos Advances in Pharmacokinetics and Pharmacodynamics Cham : Springer International Publishing AG,c2023 9783031295409 
327   $aPharmacokinetics -- Chapter 1: Current status in PBPK modeling -- Chapter 2: Physiologically based biopharmaceutics modeling (PBBM) Application on Food Effect Assessment -- Chapter 3: Physiologically based finite time pharmacokinetic (PBFTPK) models: Inception and development -- Chapter 4: Physiologically based finite time pharmacokinetic (PBFTPK) models: Applications -- Pharmacodynamics -- Chapter 5: Pharmacokinetic ? Pharmacodynamic Modelling and Simulation in Clinical Practice and Studies -- Chapter 6: On the Verge of Impossibility: Accounting for Variability Arising from Permutations of Comorbidities that Affect the Fate of Drugs in the Human Body -- Chapter 7: Impact of Clinical Pharmacology on the Modernization of Drug Development and Regulation.
330   $aThis book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
410  0$aAAPS Introductions in the Pharmaceutical Sciences,$x2522-8358 ;$v9
606   $aDrug delivery systems
606   $aDrugs$xDesign
606   $aPharmaceutical chemistry
606   $aMetabolism
606   $aPharmacology
606   $aClinical biochemistry
606   $aDrug Delivery
606   $aStructure-Based Drug Design
606   $aPharmaceutics
606   $aMetabolism
606   $aPharmacology
606   $aMedical Biochemistry
615  0$aDrug delivery systems.
615  0$aDrugs$xDesign.
615  0$aPharmaceutical chemistry.
615  0$aMetabolism.
615  0$aPharmacology.
615  0$aClinical biochemistry.
615 14$aDrug Delivery.
615 24$aStructure-Based Drug Design.
615 24$aPharmaceutics.
615 24$aMetabolism.
615 24$aPharmacology.
615 24$aMedical Biochemistry.
676   $a615.7
676   $a615.7
700   $aMacheras$b Panos$0755977
702   $aMacheras$b Panos$4oth
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
912   $a9910728396903321
996   $aAdvances in Pharmacokinetics and Pharmacodynamics$93379512
997   $aUNINA