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Structure, Activity, and Function of Protein Methyltransferases



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Autore: Jeltsch Albert Visualizza persona
Titolo: Structure, Activity, and Function of Protein Methyltransferases Visualizza cluster
Pubblicazione: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
Descrizione fisica: 1 electronic resource (292 p.)
Soggetto topico: Research & information: general
Biology, life sciences
Biochemistry
Soggetto non controllato: protein lysine methylation
H3K9 methylation
PKMT
enzyme specificity
enzyme regulation
heterochromatin
protein post-translational modification
NSD3
WHSC1L1
structure and function
protein arginine methylation
PRMT7
epigenetics
cancer
immunity
pluripotency
SETDB1
methyltransferase
schizophrenia
Huntington's disease
Rett syndrome
Prader-Willi syndrome
congenital heart diseases
inflammatory bowel disease
MLL2
structure
H3K4me3
chromatin regulation
disease
dystonia
NSD1
H3K36
SOTOS
NUP98-NSD1
AML
PRMT6
post-translational modification
H3R2me2a
SETD3
posttranslational modifications
protein histidine methylation
actin
polymerization
cytoskeleton
enteroviruses
oncogenesis
PRMT5
cardiovascular disease
neurodegenerative diseases
diabetes
inflammation
G9a
GLP
EHMT2
EHMT1
post translational modification
lysine methylation
N-terminal methylation
translation
eEF1A
METTL13
neuron
synapse
dendritic spine
actin cytoskeleton
GTPase
PRMT1
arginine methylation
H4R3 methylation
transcriptional regulation
cell signaling
DNA damage repair
PRMT2
SH3
SETMAR
Metnase
H3K36me2
Hsmar1
non-homologous end joining repair
NHEJ
transposase
transposable elements
histone
SET7/9
SETD7
lysine-specific methyltransferase (PKMT)
cell proliferation
stress response
post-translational protein modification
Persona (resp. second.): DhayalanArunkumar
JeltschAlbert
Sommario/riassunto: This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field.
Titolo autorizzato: Structure, Activity, and Function of Protein Methyltransferases  Visualizza cluster
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910566479603321
Lo trovi qui: Univ. Federico II
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