05040nam 2201465z- 450 991056647960332120231214133301.0(CKB)5680000000037584(oapen)https://directory.doabooks.org/handle/20.500.12854/81233(EXLCZ)99568000000003758420202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierStructure, Activity, and Function of Protein MethyltransferasesBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (292 p.)3-0365-4139-X 3-0365-4140-3 This collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field.Research & information: generalbicsscBiology, life sciencesbicsscBiochemistrybicsscprotein lysine methylationH3K9 methylationPKMTenzyme specificityenzyme regulationheterochromatinprotein post-translational modificationNSD3WHSC1L1structure and functionprotein arginine methylationPRMT7epigeneticscancerimmunitypluripotencySETDB1methyltransferaseschizophreniaHuntington's diseaseRett syndromePrader-Willi syndromecongenital heart diseasesinflammatory bowel diseaseMLL2structureH3K4me3chromatin regulationdiseasedystoniaNSD1H3K36SOTOSNUP98-NSD1AMLPRMT6post-translational modificationH3R2me2aSETD3posttranslational modificationsprotein histidine methylationactinpolymerizationcytoskeletonenterovirusesoncogenesisPRMT5cardiovascular diseaseneurodegenerative diseasesdiabetesinflammationG9aGLPEHMT2EHMT1post translational modificationlysine methylationN-terminal methylationtranslationeEF1AMETTL13neuronsynapsedendritic spineactin cytoskeletonGTPasePRMT1arginine methylationH4R3 methylationtranscriptional regulationcell signalingDNA damage repairPRMT2SH3SETMARMetnaseH3K36me2Hsmar1non-homologous end joining repairNHEJtransposasetransposable elementshistoneSET7/9SETD7lysine-specific methyltransferase (PKMT)cell proliferationstress responsepost-translational protein modificationResearch & information: generalBiology, life sciencesBiochemistryJeltsch Albertedt1265472Dhayalan ArunkumaredtJeltsch AlbertothDhayalan ArunkumarothBOOK9910566479603321Structure, Activity, and Function of Protein Methyltransferases3031722UNINA