LEADER 05040nam 2201465z- 450 001 9910566479603321 005 20231214133301.0 035 $a(CKB)5680000000037584 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81233 035 $a(EXLCZ)995680000000037584 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStructure, Activity, and Function of Protein Methyltransferases 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 electronic resource (292 p.) 311 $a3-0365-4139-X 311 $a3-0365-4140-3 330 $aThis collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field. 606 $aResearch & information: general$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aBiochemistry$2bicssc 610 $aprotein lysine methylation 610 $aH3K9 methylation 610 $aPKMT 610 $aenzyme specificity 610 $aenzyme regulation 610 $aheterochromatin 610 $aprotein post-translational modification 610 $aNSD3 610 $aWHSC1L1 610 $astructure and function 610 $aprotein arginine methylation 610 $aPRMT7 610 $aepigenetics 610 $acancer 610 $aimmunity 610 $apluripotency 610 $aSETDB1 610 $amethyltransferase 610 $aschizophrenia 610 $aHuntington's disease 610 $aRett syndrome 610 $aPrader-Willi syndrome 610 $acongenital heart diseases 610 $ainflammatory bowel disease 610 $aMLL2 610 $astructure 610 $aH3K4me3 610 $achromatin regulation 610 $adisease 610 $adystonia 610 $aNSD1 610 $aH3K36 610 $aSOTOS 610 $aNUP98-NSD1 610 $aAML 610 $aPRMT6 610 $apost-translational modification 610 $aH3R2me2a 610 $aSETD3 610 $aposttranslational modifications 610 $aprotein histidine methylation 610 $aactin 610 $apolymerization 610 $acytoskeleton 610 $aenteroviruses 610 $aoncogenesis 610 $aPRMT5 610 $acardiovascular disease 610 $aneurodegenerative diseases 610 $adiabetes 610 $ainflammation 610 $aG9a 610 $aGLP 610 $aEHMT2 610 $aEHMT1 610 $apost translational modification 610 $alysine methylation 610 $aN-terminal methylation 610 $atranslation 610 $aeEF1A 610 $aMETTL13 610 $aneuron 610 $asynapse 610 $adendritic spine 610 $aactin cytoskeleton 610 $aGTPase 610 $aPRMT1 610 $aarginine methylation 610 $aH4R3 methylation 610 $atranscriptional regulation 610 $acell signaling 610 $aDNA damage repair 610 $aPRMT2 610 $aSH3 610 $aSETMAR 610 $aMetnase 610 $aH3K36me2 610 $aHsmar1 610 $anon-homologous end joining repair 610 $aNHEJ 610 $atransposase 610 $atransposable elements 610 $ahistone 610 $aSET7/9 610 $aSETD7 610 $alysine-specific methyltransferase (PKMT) 610 $acell proliferation 610 $astress response 610 $apost-translational protein modification 615 7$aResearch & information: general 615 7$aBiology, life sciences 615 7$aBiochemistry 700 $aJeltsch$b Albert$4edt$01265472 702 $aDhayalan$b Arunkumar$4edt 702 $aJeltsch$b Albert$4oth 702 $aDhayalan$b Arunkumar$4oth 906 $aBOOK 912 $a9910566479603321 996 $aStructure, Activity, and Function of Protein Methyltransferases$93031722 997 $aUNINA