LEADER 05077nam 2201489z- 450 001 9910566479603321 005 20220506 035 $a(CKB)5680000000037584 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/81233 035 $a(oapen)doab81233 035 $a(EXLCZ)995680000000037584 100 $a20202205d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aStructure, Activity, and Function of Protein Methyltransferases 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (292 p.) 311 08$a3-0365-4139-X 311 08$a3-0365-4140-3 330 $aThis collection of review articles describes the structure, function and mechanism of individual protein methyltransferase enzymes including protein lysine methyltransferases, protein arginine methyltransferases, and also the less abundant protein histidine methyltransferases and protein N-terminal end methyltransferases. The topics covered in the individual reviews include structural aspects (domain architecture, homologs and paralogs, and structure), biochemical properties (mechanism, sequence specificity, product specificity, regulation, and histone and non-histone substrates), cellular features (subcellular localization, expression patterns, cellular roles and function, biological effects of substrate protein methylation, connection to cell signaling pathways, and connection to chromatin regulation) and their role in diseases. This review book is a useful resource for scientists working on protein methylation and protein methyltransferases and those interested in joining this emerging research field. 606 $aBiochemistry$2bicssc 606 $aBiology, life sciences$2bicssc 606 $aResearch & information: general$2bicssc 610 $aactin 610 $aactin cytoskeleton 610 $aAML 610 $aarginine methylation 610 $acancer 610 $acardiovascular disease 610 $acell proliferation 610 $acell signaling 610 $achromatin regulation 610 $acongenital heart diseases 610 $acytoskeleton 610 $adendritic spine 610 $adiabetes 610 $adisease 610 $aDNA damage repair 610 $adystonia 610 $aeEF1A 610 $aEHMT1 610 $aEHMT2 610 $aenteroviruses 610 $aenzyme regulation 610 $aenzyme specificity 610 $aepigenetics 610 $aG9a 610 $aGLP 610 $aGTPase 610 $aH3K36 610 $aH3K36me2 610 $aH3K4me3 610 $aH3K9 methylation 610 $aH3R2me2a 610 $aH4R3 methylation 610 $aheterochromatin 610 $ahistone 610 $aHsmar1 610 $aHuntington's disease 610 $aimmunity 610 $ainflammation 610 $ainflammatory bowel disease 610 $alysine methylation 610 $alysine-specific methyltransferase (PKMT) 610 $amethyltransferase 610 $aMetnase 610 $aMETTL13 610 $aMLL2 610 $aN-terminal methylation 610 $an/a 610 $aneurodegenerative diseases 610 $aneuron 610 $aNHEJ 610 $anon-homologous end joining repair 610 $aNSD1 610 $aNSD3 610 $aNUP98-NSD1 610 $aoncogenesis 610 $aPKMT 610 $apluripotency 610 $apolymerization 610 $apost translational modification 610 $apost-translational modification 610 $apost-translational protein modification 610 $aposttranslational modifications 610 $aPrader-Willi syndrome 610 $aPRMT1 610 $aPRMT2 610 $aPRMT5 610 $aPRMT6 610 $aPRMT7 610 $aprotein arginine methylation 610 $aprotein histidine methylation 610 $aprotein lysine methylation 610 $aprotein post-translational modification 610 $aRett syndrome 610 $aschizophrenia 610 $aSET7/9 610 $aSETD3 610 $aSETD7 610 $aSETDB1 610 $aSETMAR 610 $aSH3 610 $aSOTOS 610 $astress response 610 $astructure 610 $astructure and function 610 $asynapse 610 $atranscriptional regulation 610 $atranslation 610 $atransposable elements 610 $atransposase 610 $aWHSC1L1 615 7$aBiochemistry 615 7$aBiology, life sciences 615 7$aResearch & information: general 700 $aJeltsch$b Albert$4edt$01265472 702 $aDhayalan$b Arunkumar$4edt 702 $aJeltsch$b Albert$4oth 702 $aDhayalan$b Arunkumar$4oth 906 $aBOOK 912 $a9910566479603321 996 $aStructure, Activity, and Function of Protein Methyltransferases$93031722 997 $aUNINA