Traumatic brain injury . Part I / / Jordan Grafman, Andres M. Salazar, volume editors

• Pubblicazione: Amsterdam, Netherlands ; ; Oxford, England ; ; Waltham, Massachusetts : , : Elsevier B.V., , 2015; ©2015
• Descrizione fisica: 1 online resource (491 p.)
• Disciplina: 617.481044
• Soggetto topico: Brain - Wounds and injuries - Patients - Care; Brain - Wounds and injuries - Patients - Treatment
• Persona (resp. second.): GrafmanJordan; SalazarAndres M.
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Front Cover; Traumatic Brain Injury Part I; Copyright ; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents of Part I; Contents of Part II; Section 1: Risk and Predisposition; Chapter 1: Epidemiology of Traumatic Brain Injury; Overview: Importance of Injury and Traumatic Brain Injury; Overall Traumatic Brain Injury rates; Definitions; Cost: Burden of Injury; Severity Measures; Emergency Department rates; Trends; Hospitalizations; Trends; Deaths; Trends; Mechanism (external Causes); Peaks Within Age Groups; Gender; Race; Traumatic Brain Injury In the military ; DisabilityAlzheimer's Disease and Epilepsy; Rehabilitation; Conclusions; Disclaimer; References ; Chapter 2: Classification of Traumatic Brain Injury: Past, Present, and Future; Introduction; History of and Approaches To disease Classification; An Ideal Classification System; Classifying Traumatic Brain Injury; Defining Traumatic Brain Injury; Challenges in Classifying Traumatic Brain injury; Classifying Brain Injury By Physical Mechanism; Classifying Brain Injury By Pathoanatomy; Classifying Brain Injury By symptoms/severity; Classifying Brain Injury By Prognosis ; The Future of Traumatic Brain Injury ClassificationConclusion; References ; Chapter 3: Genetic Predictors of Outcome Following Traumatic Brain Injury; Traumatic Brain Injury is a Chronic Debilitating Condition; State of Genomics Research on Traumatic Brain Injury; Goals; Candidate Gene Approaches; APOE; COMT; BDNF; Candidate Gene Targets; Interleukins; Circadian rhythm-regulated genes; Melatonin and Its Receptors, MTNR1A and MTNR1B ; Going Beyond Candidate Gene Association Studies; Bioinformatics In GWAS; Decision Trees and Random Forests; Multifactor Dimensionality Reduction ; Role of Epigenetics in Complex DiseasesMicroRNAs in Traumatic Brain Injury; Future Directions; Define and Measure Phenotypes; The Future Of Gwas; New Approaches for Testing the Common Disease Rare Variant Hypothesis: Whole Genome Sequencing; Conclusions; Glossary; References ; Section 2: Pathology and Mechanisms of Traumatic Brain injury; Chapter 4: The Neuropathology of Traumatic Brain Injury; Introduction; Severity of Injury; Focal Versus Diffuse Injury; Primary Versus Secondary Injury; Acute moderate-severe Traumatic Brain Injury; Focal Injuries; Skull Fractures ; Contusion and Laceration ; Hemorrhage and Hematoma Diffuse Injuries; Diffuse Vascular Injury ; Diffuse Brain Swelling ; Diffuse Axonal Injury ; Excitotoxicity and Oxidative Stress ; Secondary Effects of moderate-severe Traumatic Brain Injury; Vascular Injury ; Hypoxic-Ischemic Injury ; Hypometabolism ; Neuroinflammation ; Edema and Herniation ; Acute Mild Traumatic Brain Injury; Concussive Injury; Blast Injury; Juvenile Head Trauma Syndrome and Second Impact Syndrome; Chronic Effects of Traumatic Brain Injury; Cognitive Deficits and Mood Disturbances; Alzheimer's Disease; Parkinson's Disease ; Amyotrophic Lateral Sclerosis
• Sommario/riassunto: The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumat
• Titolo autorizzato: Traumatic brain injury
• ISBN: 0-444-63498-3; 0-444-52892-X
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910583355603321
• Lo trovi qui: Univ. Federico II
• Serie: Handbook of clinical neurology ; ; Volume 127.