LEADER 05399nam 2200613 450 001 9910583355603321 005 20230120002253.0 010 $a0-444-63498-3 010 $a0-444-52892-X 035 $a(CKB)3710000000357705 035 $a(EBL)1964187 035 $a(SSID)ssj0001472618 035 $a(PQKBManifestationID)11964509 035 $a(PQKBTitleCode)TC0001472618 035 $a(PQKBWorkID)11449895 035 $a(PQKB)10656025 035 $a(MiAaPQ)EBC1964187 035 $a(EXLCZ)993710000000357705 100 $a20150306h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aTraumatic brain injury$hPart I /$fJordan Grafman, Andres M. Salazar, volume editors 210 1$aAmsterdam, Netherlands ;$aOxford, England ;$aWaltham, Massachusetts :$cElsevier B.V.,$d2015. 210 4$dİ2015 215 $a1 online resource (491 p.) 225 1 $aHandbook of Clinical Neurology ;$vVolume 127 300 $aDescription based upon print version of record. 311 $a1-336-01243-9 320 $aIncludes bibliographical references and index. 327 $aFront Cover; Traumatic Brain Injury Part I; Copyright ; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents of Part I; Contents of Part II; Section 1: Risk and Predisposition; Chapter 1: Epidemiology of Traumatic Brain Injury; Overview: Importance of Injury and Traumatic Brain Injury; Overall Traumatic Brain Injury rates; Definitions; Cost: Burden of Injury; Severity Measures; Emergency Department rates; Trends; Hospitalizations; Trends; Deaths; Trends; Mechanism (external Causes); Peaks Within Age Groups; Gender; Race; Traumatic Brain Injury In the military 327 $aDisabilityAlzheimer's Disease and Epilepsy; Rehabilitation; Conclusions; Disclaimer; References ; Chapter 2: Classification of Traumatic Brain Injury: Past, Present, and Future; Introduction; History of and Approaches To disease Classification; An Ideal Classification System; Classifying Traumatic Brain Injury; Defining Traumatic Brain Injury; Challenges in Classifying Traumatic Brain injury; Classifying Brain Injury By Physical Mechanism; Classifying Brain Injury By Pathoanatomy; Classifying Brain Injury By symptoms/severity; Classifying Brain Injury By Prognosis 327 $aThe Future of Traumatic Brain Injury ClassificationConclusion; References ; Chapter 3: Genetic Predictors of Outcome Following Traumatic Brain Injury; Traumatic Brain Injury is a Chronic Debilitating Condition; State of Genomics Research on Traumatic Brain Injury; Goals; Candidate Gene Approaches; APOE; COMT; BDNF; Candidate Gene Targets; Interleukins; Circadian rhythm-regulated genes; Melatonin and Its Receptors, MTNR1A and MTNR1B ; Going Beyond Candidate Gene Association Studies; Bioinformatics In GWAS; Decision Trees and Random Forests; Multifactor Dimensionality Reduction 327 $aRole of Epigenetics in Complex DiseasesMicroRNAs in Traumatic Brain Injury; Future Directions; Define and Measure Phenotypes; The Future Of Gwas; New Approaches for Testing the Common Disease Rare Variant Hypothesis: Whole Genome Sequencing; Conclusions; Glossary; References ; Section 2: Pathology and Mechanisms of Traumatic Brain injury; Chapter 4: The Neuropathology of Traumatic Brain Injury; Introduction; Severity of Injury; Focal Versus Diffuse Injury; Primary Versus Secondary Injury; Acute moderate-severe Traumatic Brain Injury; Focal Injuries; Skull Fractures ; Contusion and Laceration 327 $aHemorrhage and Hematoma Diffuse Injuries; Diffuse Vascular Injury ; Diffuse Brain Swelling ; Diffuse Axonal Injury ; Excitotoxicity and Oxidative Stress ; Secondary Effects of moderate-severe Traumatic Brain Injury; Vascular Injury ; Hypoxic-Ischemic Injury ; Hypometabolism ; Neuroinflammation ; Edema and Herniation ; Acute Mild Traumatic Brain Injury; Concussive Injury; Blast Injury; Juvenile Head Trauma Syndrome and Second Impact Syndrome; Chronic Effects of Traumatic Brain Injury; Cognitive Deficits and Mood Disturbances; Alzheimer's Disease; Parkinson's Disease 327 $aAmyotrophic Lateral Sclerosis 330 $aThe Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumat 410 0$aHandbook of clinical neurology ;$vVolume 127. 606 $aBrain$xWounds and injuries$xPatients$xCare 606 $aBrain$xWounds and injuries$xPatients$xTreatment 615 0$aBrain$xWounds and injuries$xPatients$xCare. 615 0$aBrain$xWounds and injuries$xPatients$xTreatment. 676 $a617.481044 702 $aGrafman$b Jordan 702 $aSalazar$b Andres M. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910583355603321 996 $aTraumatic brain injury$91922102 997 $aUNINA