Secondary Metabolites and Drug Discovery

• Autore: Dar Umar Ali
• Pubblicazione: Newark : , : John Wiley & Sons, Incorporated, , 2025; ©2025
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (525 pages)
• Disciplina: 615.19
• Altri autori: ShahnawazMohd SinghNeha
• Nota di contenuto: Cover -- Series Page -- Title Page -- Copyright Page -- Dedication Page -- Contents -- Preface -- Acknowledgment -- Chapter 1 Drug Discovery and Secondary Metabolites: An Overview -- 1.1 Introduction -- 1.2 Phytochemicals -- 1.3 Secondary Metabolites as Major Resources for Potent Drug Discovery -- 1.4 Conclusion -- Acknowledgment -- References -- Chapter 2 Relationship Between Allopathic Medicine and Secondary Metabolites: Opportunities in Drug Discovery -- 2.1 Introduction -- 2.2 History of Secondary Metabolites -- 2.3 Secondary Metabolites -- 2.3.1 Secondary Metabolites from Plants -- 2.3.2 Biosynthesis of Secondary Metabolites in Plants -- 2.3.3 Secondary Metabolites from Microorganism -- 2.3.3.1 Antibiotics -- 2.3.3.2 Anticancer -- 2.3.4 Secondary Metabolites from Endophytic Microorganisms -- 2.3.4.1 Antibiotics -- 2.3.4.2 Lipopeptides -- 2.3.4.3 Anticancer Agents -- 2.3.4.4 Cyclic Analogs -- 2.3.4.5 Antiviral Agents -- 2.3.4.6 Flavonoids -- 2.3.4.7 Terpenoids and Alkaloids -- 2.4 Modern Techniques Involved in the Production of Secondary Metabolites -- 2.4.1 Manipulation of Secondary Metabolic Clusters' Genetic Control -- 2.4.2 BGCs' Heterogeneous Expression and Refactoring -- 2.4.3 Utilizing Nutrition and Small Molecules -- 2.5 Future Direction and Conclusion -- Acknowledgment -- References -- Chapter 3 Endophytic Microorganisms in Traditional and Modern Plant-Based Medicine: Diversity, Biomedical Applications, and Future Prospects -- 3.1 Introduction -- 3.2 Endophytic Microorganisms in Traditional Plant-Based Medicine -- 3.3 Ayurveda and Indian Traditional Medicine -- 3.3.1 Diversity of Endophytic Microorganisms -- 3.3.2 Medicinal Properties and Uses -- 3.3.2.1 Thespesia populnea -- 3.3.2.2 Datura metel -- 3.3.2.3 Mucuna pruriens -- 3.4 Traditional Chinese Medicine -- 3.4.1 Diversity of Endophytic Microorganism. ; 3.4.2 Medicinal Properties and Uses -- 3.4.2.1 Mammals -- 3.4.2.2 Reptiles and Amphibians -- 3.4.2.3 Marine Life -- 3.4.2.4 Plants -- 3.4.2.5 Inorganic Chemicals and Minerals -- 3.5 Immunomodulatory Effects -- 3.6 Cancer Therapeutics -- 3.7 Antibiotic Production -- 3.8 Biotechnological and Agricultural Applications of Endophytic Microorganisms -- 3.8.1 Plant Growth Promotion -- 3.8.2 Biological Control of Plant Pathogens -- 3.8.3 Stress Tolerance -- 3.9 Future Directions for Research and Development -- 3.9.1 Methodological Advances -- 3.9.2 Cultivation-Independent Strategies for Studying Endophytic Fungus -- 3.9.3 Biomedical and Biotechnological Challenges -- 3.9.4 Genomics of Endophytes -- 3.9.5 Bioremediation -- 3.10 Future Research Directions -- 3.11 Conclusion -- References -- Chapter 4 Historical and Current Scenario of Ayurvedic, Unani, and Chinese Medical Systems -- 4.1 History, Present, and Future of Traditional Medicine Techniques -- 4.2 Traditional Chinese Medicine (TCM) -- 4.3 Ayurvedic Medicine -- 4.4 Unani Medicine -- 4.5 Conclusion -- References -- Chapter 5 Historical and Present Scenario of Folklore System of Medicine, Homeopathic System of Medicine -- 5.1 Introduction to Folklore System of Medicine -- 5.1.1 Knowledge Transmission of the Folk Medicine -- 5.1.2 Official and Unofficial Culture -- 5.1.3 Benefits, Risks, and Questions of Efficacy -- 5.1.4 Folk Medicine and Cosmopolitan Medicine -- 5.1.5 Folk Medicine and Modern Medicine -- 5.1.6 Historical Scenario -- 5.1.7 Colonial America -- 5.1.8 Folk Treatments -- 5.1.8.1 Natural Substances -- 5.1.8.2 Physical Therapies -- 5.1.9 Present Scenario -- 5.1.9.1 Women's Health and Folk Medicine -- 5.1.9.2 Interaction with Other Systems -- 5.2 Homeopathic System of Medicine -- 5.2.1 Introduction to Homeopathy -- 5.2.2 Historical Milestones -- 5.2.3 Principal Framework -- 5.2.4 Homeopathy. ; 5.2.4.1 Sources -- 5.2.4.2 Preparations -- 5.2.5 Present Status -- 5.2.6 Future Prospect -- 5.3 Conclusion -- Acknowledgement -- References -- Chapter 6 Alternative System of Medicine vs. Traditional System of Medicine -- 6.1 Introduction -- 6.1.1 Traditional Medicinal Practices -- 6.1.2 Complementary and Alternative Medical Care -- 6.2 Contextual -- 6.2.1 Biologically Based Practices -- 6.2.2 Manipulative and Physiological Approaches -- 6.2.3 Mind-Body Medicine -- 6.2.4 Energy-Based Medicine -- 6.2.5 Alternative Medicinal Systems -- 6.3 What is Alternative Medicine? -- 6.4 Different Types of Alternative System of Medicines in India -- 6.4.1 Ayurveda -- 6.4.2 Unani Medicine -- 6.4.3 Homeopathy -- 6.4.4 Siddha -- 6.4.5 Sowa-Ripa -- 6.4.6 Acupuncture -- 6.4.7 Yoga and Naturopathy -- 6.4.8 Other Alternative Modalities -- 6.4.8.1 Chiropractic Medicine -- 6.4.8.2 Herbal Medicine -- 6.4.8.3 Mind-Body Therapies -- 6.4.8.4 Biologically Based Practices -- 6.4.8.5 Some Commonly Used Herbal Supplements -- 6.4.8.6 Manipulative and Body-Based Practices -- 6.4.8.7 Energy Healing -- 6.5 Future Scope of Traditional Medicine -- 6.6 Traditional Indian Medicine History -- 6.7 Development of Traditional Indian Medicine -- 6.7.1 Overall System of Management -- 6.7.2 Policy -- 6.7.3 Education -- 6.7.4 Medical Treatment -- 6.7.5 Drugs -- 6.7.6 Scientific Research -- 6.7.7 Industry -- 6.7.8 Intellectual Property Protection -- 6.7.9 Pharmacovigilance System -- 6.8 Why People Use Alternative Medicines? -- 6.8.1 National Policy and Regulation -- 6.8.2 Safety, Efficacy, and Quality -- 6.8.3 Access -- 6.8.4 Rational Use -- 6.9 Alternative Medicine and Its Importance -- 6.9.1 Challenges -- 6.9.2 Initiatives for AYUSH Promotion -- 6.9.3 Measures to be Taken for Integrating AYUSH -- 6.9.4 However, Prerequisites of Such Integration Need Substantial Groundwork. ; 6.10 Global Use of Traditional Medicine -- 6.10.1 Diagnosis in Ayurveda -- 6.10.2 Treatment in Ayurveda -- 6.10.3 Ayurveda Characteristics -- 6.10.4 Advantages of Clinical Treatment -- 6.11 Conclusion -- References -- Chapter 7 Cost, Benefits, and Side Effects of Alternative, Complementary, and Traditional Medicine to Control Non-Communicable Diseases -- 7.1 Introduction -- 7.1.1 Costs of ACTM for NCDs -- 7.1.1.1 Direct Costs of ACTM -- 7.1.1.2 Indirect Costs of ACTM -- 7.1.2 ACTM for NCDs: The Cost Beyond the Dollar -- 7.1.2.1 Financial Cost Transparency -- 7.1.2.2 Insurance Coverage and Cost Sharing -- 7.1.2.3 Cost-Effectiveness Analysis -- 7.1.2.4 Societal Cost Considerations -- 7.2 Benefits of ACTM for NCDs -- 7.2.1 Reduced Side Effects -- 7.2.2 Holistic Approach to Health -- 7.2.3 Patient-Centered Care -- 7.2.4 Psychological Well-Being -- 7.2.5 Potential Benefits for Specific NCDs -- 7.3 Holistic Approach to Health Management -- 7.4 Side Effects and Risks of ACTM for NCDs -- 7.4.1 Potential for Adverse Reactions -- 7.4.2 Interactions with Conventional Medicine -- 7.4.3 Strategies for Mitigating Risks -- 7.4.4 Encourage Open Communication and Disclosure -- 7.4.5 Educate Patients and Healthcare Providers -- 7.4.6 Ensure Practitioner Qualifications -- 7.4.7 Implement Safety and Quality Standards -- 7.4.8 Utilize Technology for Monitoring and Management -- 7.4.9 Adopt a Holistic and Personalized Approach -- 7.5 Comparative Analysis: ACTM vs. Conventional Medicine for NCDs -- 7.5.1 Prevalence and Utilization -- 7.5.2 Patient Satisfaction -- 7.5.3 Safety Concerns -- 7.5.4 Systems Medicine and Integrated Care -- 7.5.5 Coverage and Evidence Development -- 7.5.6 Determinants of CAM Use -- 7.6 Integration and Considerations of ACTMs for NCDs -- 7.7 Conclusions -- Acknowledgements -- References -- Chapter 8 Integrative Medicine: An Overview. ; 8.1 Introduction -- 8.2 Overview of Integrative Medicine -- 8.3 Current Contributions -- 8.4 Integrative Vision of Healthcare-Public Health: Policy and Recommendations -- 8.5 Benefits of Integrative Medicine -- 8.6 Integrative Mental Health -- 8.7 Integrative Medicine for the Underserved -- 8.8 Philosophy of Integrative Medicine -- 8.9 Relationship-Centered Care -- 8.10 Prevention -- 8.11 Integration -- 8.12 Conclusion -- Acknowledgment -- References -- Chapter 9 Different Sources and Types of Drug Molecules Used in Homeopathy System of Medicine -- 9.1 Introduction -- 9.2 Brief History of Homeopathy -- 9.3 Homeopathy System of Medicine -- 9.4 The Art and Science of Drugs in Homeopathy -- 9.5 Source and Types of Drug Molecules Used in Homeopathic System of Medicine -- 9.5.1 Plant Kingdom -- 9.5.2 Animal Kingdom -- 9.5.3 Mineral Kingdom -- 9.5.4 Sarcodes -- 9.5.5 Nosodes -- 9.5.6 Imponderabilia -- 9.5.7 Synthetic Sources of Some Drugs -- 9.6 Criticism on Homeopathic System of Medicine -- 9.7 Limitation of Drug Molecules Used in Homeopathy -- 9.8 Future Direction and Drug Discovery -- 9.9 Conclusion -- Acknowledgement -- References -- Chapter 10 Cost, Benefits, and Side Effects of Allopathic Medicine to Control Communicable Diseases -- 10.1 Background -- 10.2 Etiopathogenesis of Common Communicable Diseases -- 10.2.1 Viral Communicable Disease -- 10.2.2 Bacterial Communicable Diseases -- 10.2.3 Etiopathogenesis of Non-Viral and Non-Bacterial Communicable Diseases -- 10.3 Sign and Symptoms of Communicable Disease -- 10.4 Mode of Transmission of Communicable Diseases -- 10.5 Preventive Measures of Communicable Diseases -- 10.6 Cost and Benefit of Current Allopathic Medicine for the Treatment of Communicable Diseases -- 10.7 Side Effects of Allopathic Medicine to Control Communicable Diseases -- 10.7.1 Tuberculosis -- 10.7.2 Malaria -- 10.7.3 Cholera. ; 10.7.4 Measles.
• Sommario/riassunto: This book explores the promising potential of plant and microbe-derived compounds in drug discovery, offering insights into safer alternatives to synthetic drugs and highlighting the vital role of natural products in treating diseases with fewer side effects.
• Titolo autorizzato: Secondary Metabolites and Drug Discovery
• ISBN: 1-394-20459-0; 1-394-20457-4; 1-394-20458-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9911021977103321
• Lo trovi qui: Univ. Federico II