10871nam 22005053 450 991102197710332120250830060330.01-394-20459-01-394-20457-41-394-20458-2(CKB)40377778600041(MiAaPQ)EBC32272804(Au-PeEL)EBL32272804(OCoLC)1534811857(EXLCZ)994037777860004120250830d2025 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierSecondary Metabolites and Drug Discovery1st ed.Newark :John Wiley & Sons, Incorporated,2025.©2025.1 online resource (525 pages)1-394-20434-5 Cover -- Series Page -- Title Page -- Copyright Page -- Dedication Page -- Contents -- Preface -- Acknowledgment -- Chapter 1 Drug Discovery and Secondary Metabolites: An Overview -- 1.1 Introduction -- 1.2 Phytochemicals -- 1.3 Secondary Metabolites as Major Resources for Potent Drug Discovery -- 1.4 Conclusion -- Acknowledgment -- References -- Chapter 2 Relationship Between Allopathic Medicine and Secondary Metabolites: Opportunities in Drug Discovery -- 2.1 Introduction -- 2.2 History of Secondary Metabolites -- 2.3 Secondary Metabolites -- 2.3.1 Secondary Metabolites from Plants -- 2.3.2 Biosynthesis of Secondary Metabolites in Plants -- 2.3.3 Secondary Metabolites from Microorganism -- 2.3.3.1 Antibiotics -- 2.3.3.2 Anticancer -- 2.3.4 Secondary Metabolites from Endophytic Microorganisms -- 2.3.4.1 Antibiotics -- 2.3.4.2 Lipopeptides -- 2.3.4.3 Anticancer Agents -- 2.3.4.4 Cyclic Analogs -- 2.3.4.5 Antiviral Agents -- 2.3.4.6 Flavonoids -- 2.3.4.7 Terpenoids and Alkaloids -- 2.4 Modern Techniques Involved in the Production of Secondary Metabolites -- 2.4.1 Manipulation of Secondary Metabolic Clusters' Genetic Control -- 2.4.2 BGCs' Heterogeneous Expression and Refactoring -- 2.4.3 Utilizing Nutrition and Small Molecules -- 2.5 Future Direction and Conclusion -- Acknowledgment -- References -- Chapter 3 Endophytic Microorganisms in Traditional and Modern Plant-Based Medicine: Diversity, Biomedical Applications, and Future Prospects -- 3.1 Introduction -- 3.2 Endophytic Microorganisms in Traditional Plant-Based Medicine -- 3.3 Ayurveda and Indian Traditional Medicine -- 3.3.1 Diversity of Endophytic Microorganisms -- 3.3.2 Medicinal Properties and Uses -- 3.3.2.1 Thespesia populnea -- 3.3.2.2 Datura metel -- 3.3.2.3 Mucuna pruriens -- 3.4 Traditional Chinese Medicine -- 3.4.1 Diversity of Endophytic Microorganism.3.4.2 Medicinal Properties and Uses -- 3.4.2.1 Mammals -- 3.4.2.2 Reptiles and Amphibians -- 3.4.2.3 Marine Life -- 3.4.2.4 Plants -- 3.4.2.5 Inorganic Chemicals and Minerals -- 3.5 Immunomodulatory Effects -- 3.6 Cancer Therapeutics -- 3.7 Antibiotic Production -- 3.8 Biotechnological and Agricultural Applications of Endophytic Microorganisms -- 3.8.1 Plant Growth Promotion -- 3.8.2 Biological Control of Plant Pathogens -- 3.8.3 Stress Tolerance -- 3.9 Future Directions for Research and Development -- 3.9.1 Methodological Advances -- 3.9.2 Cultivation-Independent Strategies for Studying Endophytic Fungus -- 3.9.3 Biomedical and Biotechnological Challenges -- 3.9.4 Genomics of Endophytes -- 3.9.5 Bioremediation -- 3.10 Future Research Directions -- 3.11 Conclusion -- References -- Chapter 4 Historical and Current Scenario of Ayurvedic, Unani, and Chinese Medical Systems -- 4.1 History, Present, and Future of Traditional Medicine Techniques -- 4.2 Traditional Chinese Medicine (TCM) -- 4.3 Ayurvedic Medicine -- 4.4 Unani Medicine -- 4.5 Conclusion -- References -- Chapter 5 Historical and Present Scenario of Folklore System of Medicine, Homeopathic System of Medicine -- 5.1 Introduction to Folklore System of Medicine -- 5.1.1 Knowledge Transmission of the Folk Medicine -- 5.1.2 Official and Unofficial Culture -- 5.1.3 Benefits, Risks, and Questions of Efficacy -- 5.1.4 Folk Medicine and Cosmopolitan Medicine -- 5.1.5 Folk Medicine and Modern Medicine -- 5.1.6 Historical Scenario -- 5.1.7 Colonial America -- 5.1.8 Folk Treatments -- 5.1.8.1 Natural Substances -- 5.1.8.2 Physical Therapies -- 5.1.9 Present Scenario -- 5.1.9.1 Women's Health and Folk Medicine -- 5.1.9.2 Interaction with Other Systems -- 5.2 Homeopathic System of Medicine -- 5.2.1 Introduction to Homeopathy -- 5.2.2 Historical Milestones -- 5.2.3 Principal Framework -- 5.2.4 Homeopathy.5.2.4.1 Sources -- 5.2.4.2 Preparations -- 5.2.5 Present Status -- 5.2.6 Future Prospect -- 5.3 Conclusion -- Acknowledgement -- References -- Chapter 6 Alternative System of Medicine vs. Traditional System of Medicine -- 6.1 Introduction -- 6.1.1 Traditional Medicinal Practices -- 6.1.2 Complementary and Alternative Medical Care -- 6.2 Contextual -- 6.2.1 Biologically Based Practices -- 6.2.2 Manipulative and Physiological Approaches -- 6.2.3 Mind-Body Medicine -- 6.2.4 Energy-Based Medicine -- 6.2.5 Alternative Medicinal Systems -- 6.3 What is Alternative Medicine? -- 6.4 Different Types of Alternative System of Medicines in India -- 6.4.1 Ayurveda -- 6.4.2 Unani Medicine -- 6.4.3 Homeopathy -- 6.4.4 Siddha -- 6.4.5 Sowa-Ripa -- 6.4.6 Acupuncture -- 6.4.7 Yoga and Naturopathy -- 6.4.8 Other Alternative Modalities -- 6.4.8.1 Chiropractic Medicine -- 6.4.8.2 Herbal Medicine -- 6.4.8.3 Mind-Body Therapies -- 6.4.8.4 Biologically Based Practices -- 6.4.8.5 Some Commonly Used Herbal Supplements -- 6.4.8.6 Manipulative and Body-Based Practices -- 6.4.8.7 Energy Healing -- 6.5 Future Scope of Traditional Medicine -- 6.6 Traditional Indian Medicine History -- 6.7 Development of Traditional Indian Medicine -- 6.7.1 Overall System of Management -- 6.7.2 Policy -- 6.7.3 Education -- 6.7.4 Medical Treatment -- 6.7.5 Drugs -- 6.7.6 Scientific Research -- 6.7.7 Industry -- 6.7.8 Intellectual Property Protection -- 6.7.9 Pharmacovigilance System -- 6.8 Why People Use Alternative Medicines? -- 6.8.1 National Policy and Regulation -- 6.8.2 Safety, Efficacy, and Quality -- 6.8.3 Access -- 6.8.4 Rational Use -- 6.9 Alternative Medicine and Its Importance -- 6.9.1 Challenges -- 6.9.2 Initiatives for AYUSH Promotion -- 6.9.3 Measures to be Taken for Integrating AYUSH -- 6.9.4 However, Prerequisites of Such Integration Need Substantial Groundwork.6.10 Global Use of Traditional Medicine -- 6.10.1 Diagnosis in Ayurveda -- 6.10.2 Treatment in Ayurveda -- 6.10.3 Ayurveda Characteristics -- 6.10.4 Advantages of Clinical Treatment -- 6.11 Conclusion -- References -- Chapter 7 Cost, Benefits, and Side Effects of Alternative, Complementary, and Traditional Medicine to Control Non-Communicable Diseases -- 7.1 Introduction -- 7.1.1 Costs of ACTM for NCDs -- 7.1.1.1 Direct Costs of ACTM -- 7.1.1.2 Indirect Costs of ACTM -- 7.1.2 ACTM for NCDs: The Cost Beyond the Dollar -- 7.1.2.1 Financial Cost Transparency -- 7.1.2.2 Insurance Coverage and Cost Sharing -- 7.1.2.3 Cost-Effectiveness Analysis -- 7.1.2.4 Societal Cost Considerations -- 7.2 Benefits of ACTM for NCDs -- 7.2.1 Reduced Side Effects -- 7.2.2 Holistic Approach to Health -- 7.2.3 Patient-Centered Care -- 7.2.4 Psychological Well-Being -- 7.2.5 Potential Benefits for Specific NCDs -- 7.3 Holistic Approach to Health Management -- 7.4 Side Effects and Risks of ACTM for NCDs -- 7.4.1 Potential for Adverse Reactions -- 7.4.2 Interactions with Conventional Medicine -- 7.4.3 Strategies for Mitigating Risks -- 7.4.4 Encourage Open Communication and Disclosure -- 7.4.5 Educate Patients and Healthcare Providers -- 7.4.6 Ensure Practitioner Qualifications -- 7.4.7 Implement Safety and Quality Standards -- 7.4.8 Utilize Technology for Monitoring and Management -- 7.4.9 Adopt a Holistic and Personalized Approach -- 7.5 Comparative Analysis: ACTM vs. Conventional Medicine for NCDs -- 7.5.1 Prevalence and Utilization -- 7.5.2 Patient Satisfaction -- 7.5.3 Safety Concerns -- 7.5.4 Systems Medicine and Integrated Care -- 7.5.5 Coverage and Evidence Development -- 7.5.6 Determinants of CAM Use -- 7.6 Integration and Considerations of ACTMs for NCDs -- 7.7 Conclusions -- Acknowledgements -- References -- Chapter 8 Integrative Medicine: An Overview.8.1 Introduction -- 8.2 Overview of Integrative Medicine -- 8.3 Current Contributions -- 8.4 Integrative Vision of Healthcare-Public Health: Policy and Recommendations -- 8.5 Benefits of Integrative Medicine -- 8.6 Integrative Mental Health -- 8.7 Integrative Medicine for the Underserved -- 8.8 Philosophy of Integrative Medicine -- 8.9 Relationship-Centered Care -- 8.10 Prevention -- 8.11 Integration -- 8.12 Conclusion -- Acknowledgment -- References -- Chapter 9 Different Sources and Types of Drug Molecules Used in Homeopathy System of Medicine -- 9.1 Introduction -- 9.2 Brief History of Homeopathy -- 9.3 Homeopathy System of Medicine -- 9.4 The Art and Science of Drugs in Homeopathy -- 9.5 Source and Types of Drug Molecules Used in Homeopathic System of Medicine -- 9.5.1 Plant Kingdom -- 9.5.2 Animal Kingdom -- 9.5.3 Mineral Kingdom -- 9.5.4 Sarcodes -- 9.5.5 Nosodes -- 9.5.6 Imponderabilia -- 9.5.7 Synthetic Sources of Some Drugs -- 9.6 Criticism on Homeopathic System of Medicine -- 9.7 Limitation of Drug Molecules Used in Homeopathy -- 9.8 Future Direction and Drug Discovery -- 9.9 Conclusion -- Acknowledgement -- References -- Chapter 10 Cost, Benefits, and Side Effects of Allopathic Medicine to Control Communicable Diseases -- 10.1 Background -- 10.2 Etiopathogenesis of Common Communicable Diseases -- 10.2.1 Viral Communicable Disease -- 10.2.2 Bacterial Communicable Diseases -- 10.2.3 Etiopathogenesis of Non-Viral and Non-Bacterial Communicable Diseases -- 10.3 Sign and Symptoms of Communicable Disease -- 10.4 Mode of Transmission of Communicable Diseases -- 10.5 Preventive Measures of Communicable Diseases -- 10.6 Cost and Benefit of Current Allopathic Medicine for the Treatment of Communicable Diseases -- 10.7 Side Effects of Allopathic Medicine to Control Communicable Diseases -- 10.7.1 Tuberculosis -- 10.7.2 Malaria -- 10.7.3 Cholera.10.7.4 Measles.This book explores the promising potential of plant and microbe-derived compounds in drug discovery, offering insights into safer alternatives to synthetic drugs and highlighting the vital role of natural products in treating diseases with fewer side effects.615.19Dar Umar Ali1837359Shahnawaz Mohd872809Singh Neha1280228MiAaPQMiAaPQMiAaPQBOOK9911021977103321Secondary Metabolites and Drug Discovery4429239UNINA