Cell Biology and Translational Medicine, Volume 12 : Stem Cells in Development and Disease

• Autore: Turksen Kursad
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2021; ©2021
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (190 pages)
• Disciplina: 571.6
• Soggetto topico: Citologia; Ciències de la salut
• Soggetto genere / forma: Llibres electrònics
• Nota di contenuto: Intro -- Preface -- Contents -- Immune Dysregulation and Recurring Mutations in Myelodysplastic Syndromes Pathogenesis -- 1 Introduction: Immune Dysregulation in MDS -- 2 MDSC: Pathways of Activation and Pathogenesis in MDS -- 3 Considerations for Clonal, Pre-MDS States: CHIP and CCUS -- 4 Conclusions -- References -- Stem Cell Aging and Regenerative Medicine -- 1 Introduction -- 2 Stem Cell Aging -- 2.1 ROS -- 2.2 Mitochondria -- 2.3 Proteostasis -- 2.4 DNA Damage -- 2.5 Telomere -- 2.6 Epigenetics -- 3 Stem Cells in Regenerative Medicine -- 3.1 Embryonic Stem Cells in Regenerative Medicine -- 3.2 Therapeutic Cloning -- 3.3 Adult Stem Cells in Regenerative Medicine -- 3.4 Hematopoietic Stem Cells -- 3.5 Neural Stem Cells -- 3.6 Mesenchymal Stem Cells -- 3.7 Heart -- 3.8 Liver -- 3.9 Pancreas -- 3.10 Lungs -- 3.11 Kidney -- 3.12 Urinary Bladder -- 3.13 Dentistry -- 3.14 Plastic and Reconstructive Surgery -- 3.15 Organoids -- 4 Stem Cell Aging in Regenerative Medicine -- 4.1 Age-Related Clonal Haematopoiesis -- 4.2 Impact of Age on T Cell Recovery after Bone Marrow Transplantation -- 4.3 Age-Related Challenges of Regenerative Therapy by Bone Marrow Derived Mesenchymal Stromal Cells -- 4.4 Aging and Wound Repair by Mesenchymal Stem Cells -- 4.5 Age-Related Challenges of Regenerative Therapy by Adipose-Derived Stem Cells -- 4.6 Stem Cell Aging and Derivation of Induced Pluripotent Stem Cells -- 5 Conclusion -- References -- Potential of Chimeric Antigen Receptor T-Cells in Cancer Therapy -- 1 Introduction -- 2 CAR T-Cell Derived for Cancer Treatment -- 3 Factors Affecting Efficacy and Safety of CAR T-Cell Therapy -- 4 Overcoming the Toxicities -- 5 Clinical Trials -- 6 Conclusions -- References -- Drug Sensitivity and Drug Repurposing Platform for Cancer Precision Medicine -- 1 Introduction. ; 2 Tumour Heterogeneity: Origin and Role in Drug Resistance -- 3 Drug Sensitivity and Repurposing in Cancer -- 4 High Throughput Screening Platform -- 5 Future Perspective -- References -- Role and Regulation of Lin28 in Progenitor Cells During Central Nervous System Development -- 1 Introduction -- 2 Overview of the CNS Development in Mice -- 3 Expression of Lin28a and Lin28b during CNS Development in Mice -- 3.1 Endogenous Expression During Embryogenesis and Post-natal Development -- 3.2 Regulation of Lin28a and Lin28b in Neural Stem and Progenitor Cells -- 4 Role of Lin28 in Proliferation and Cell Fate Decisions in the CNS -- 5 Molecular Mechanisms Underlying the Role of Lin28 in the CNS -- 6 Reactivation of Lin28 in NS Regeneration and Misregulation in Diseases -- 7 Perspectives -- References -- Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives -- 1 Introduction -- 2 Articular Cartilage Structure, Injuries, and Repair -- 2.1 Articular Cartilage Structure and Function -- 2.2 Articular Cartilage Injuries and their Repair -- 2.2.1 Traditional Treatment of Cartilage Defects -- 2.2.2 Novel Tissue Engineering and Cell-Based Methods -- 3 Exosomes (Exos) as a Promising Substitute for Cell Therapy -- 3.1 Isolation and Characterization of Exosomes (Exos) -- 3.2 Clinical Applications of Stem Cell-Derived Exosomes (Exos) in Cartilage Defects -- 3.3 Limitations, Future Trends, and Concluding Remarks -- References -- Kaempferol Induces Cell Death and Sensitizes Human Head and Neck Squamous Cell Carcinoma Cell Lines to Cisplatin -- 1 Introduction -- 2 Results -- 2.1 Cytotoxic and Antiproliferative Effects of Kaempferol on Head and Neck Tumor Cells -- 2.2 Effects of Kaempferol on Mitochondrial Function. ; 2.3 Effects of Kaempferol on Mitochondrial Transmembrane Potential and Intracellular ATP Content -- 2.4 Effects of Kaempferol on Tumor Cell Migration -- 2.5 Effects of Kaempferol on Induction of Apoptosis -- 2.6 Effects of Kaempferol in Combination with Cisplatin -- 3 Discussion -- 4 Materials and Methods -- 4.1 Chemical and Reagents -- 4.2 Cell Lines and Cell Culture -- 4.3 Cell Viability Assay -- 4.4 Colony Assay -- 4.5 Oxygen Consumption Assay -- 4.6 Mitochondrial Transmembrane Potential (DeltaPsim) -- 4.7 Intracellular ATP Levels -- 4.8 Apoptosis Induction -- 4.9 Scratch Assays -- 4.10 Tumor Cells Migration Assay -- 4.11 Activation of Metalloproteinases and VEGF by Western Blot Analysis -- References -- A Comprehensive Approach to Urticaria: From Clinical Presentation to Modern Biological Treatments Through Pathogenesis -- 1 Definition -- 2 Classification -- 3 Epidemiology and Genetics -- 4 Pathogenesis -- 4.1 Acute Urticaria -- 4.2 Chronic Urticaria -- 4.2.1 Cellular Alterations -- Mast Cells -- Basophils -- 4.2.2 Humoral Alterations -- Complement -- Coagulation -- 4.2.3 Extrinsic Precipitating Factors -- 5 Diagnosis -- 5.1 Diagnostic Workup -- 5.2 Biomarkers of Diagnosis and Severity -- 5.3 Differential Diagnosis -- 6 Treatment -- 6.1 Acute Urticaria -- 6.2 Chronic Urticaria -- 6.2.1 Chronic Inducible Urticaria -- 6.2.2 Chronic Spontaneous Urticaria -- Identification and Avoidance of Aggravating Factors -- Pharmacological Management: A Stepwise Approach -- Biomarkers of Response to Treatment -- 6.3 Investigational Therapies -- 6.3.1 Anti-IgE Humanized Monoclonal Antibodies -- 6.3.2 Blockade of IL-1 -- 6.3.3 DARPins -- 6.3.4 SYK Inhibitors -- 6.3.5 BTK Inhibitors -- 6.3.6 Anti-Prostaglandin -- 6.3.7 Anti-Complement Fragments -- 6.3.8 Anti-IL-5 and IL-5 Receptors -- 6.3.9 Anti Sialic Acid-Binding Immunoglobulin-like Lectins (Siglecs). ; 7 Prognosis -- References -- The Potentials and Pitfalls of Using Adult Stem Cells in Cancer Treatment -- 1 Introduction -- 2 Stem Cells: Overview and Classification -- 2.1 Human Embryonic Stem Cells (hESCs) -- 2.2 Somatic Stem Cells -- 2.2.1 Haematopoietic Stem Cells -- 2.2.2 Mesenchymal Stem Cells -- 2.2.3 Neural Stem Cells -- 2.3 Induced Pluripotent Stem Cells -- 3 Therapeutic Application of Stem Cells in Cancer Treatment -- 3.1 Application of Stem Cells as Carriers of Therapeutic Payload -- 3.1.1 Mechanisms for the Tumor Tropism of Stem Cells -- 3.1.2 Stem Cells as Carriers in Gene Therapy -- 3.1.3 Delivery of OVs by Stem Cells -- 3.1.4 Delivery of Therapeutic EVs by Stem Cells -- Types of EVs -- Stem Cell-Derived EVs in Cancer Treatment -- Nucleic Acid and Protein Loading in EVs Derived from Stem Cells -- Drug Loading in Stem Cell-Derived EVs -- 3.1.5 Delivery Route -- 3.1.6 Clinical Scenarios of Stem Cell-Based Anti-cancer Treatment Regimens -- 3.1.7 Challenges of Using Stem Cells as Delivery Vehicles for Therapeutic Payloads -- Longevity -- Immunosuppression -- Safety Issues -- Compatibility -- 4 Application of Stem Cells in Regenerative Medicine -- 4.1 Homing to Bone Marrow -- 4.2 Satus quo of Stem Cell-Based Regenerative Regimen in Cancer Treatment -- 4.2.1 HSC-Based Regenerative Regimen -- 4.2.2 MSC-Based Regenerative Regimen -- 4.2.3 iPSC-Based Regenerative Regimen -- 4.3 Challenges Associated with Stem Cell-Based Regenerative Regimen -- 5 Concluding Remarks -- References -- The Outcome of Stem Cell-Based Therapies on the Immune Responses in Rheumatoid Arthritis -- 1 Introduction -- 2 Rheumatoid Arthritis -- 2.1 Symptoms and Causes -- 2.2 Mechanisms of the Disease -- 2.2.1 Immune Responses of the Disease and Involved Cytokines -- 3 Treatment Approaches for Rheumatoid Arthritis -- 3.1 Non-steroidal Anti-inflammatory Drugs. ; 3.2 Conventional Disease-Modifying Anti-rheumatic Drugs -- 3.3 Biological Agents -- 4 An Introduction to Stem Cell Medicine -- 4.1 Sources of Stem Cells -- 4.2 The Therapeutic Effects of Stem Cell-Based Strategies on Some Disorders with Immune Pathways -- 5 Stem Cell-Based Therapies and the Immune Responses of Rheumatoid Arthritis -- 5.1 Mesenchymal Stem Cell Transplantation -- 5.2 Hematopoietic Stem Cell Transplantation -- 6 Conclusion, Limitations and Future Perspectives -- References -- Index.
• Sommario/riassunto: Much research has focused on the basic cellular and molecular biological aspects of stem cells.Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies.
• Altri titoli varianti: Cell Biology and Translational Medicine, Volume 12
• Titolo autorizzato: Cell Biology and Translational Medicine, Volume 12
• ISBN: 3-030-71933-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910495200203321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in Experimental Medicine and Biology