Impaired Mitochondrial Bioenergetics under Pathological Conditions

• Autore: Lenaz Giorgio
• Pubblicazione: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
• Descrizione fisica: 1 online resource (460 p.)
• Soggetto topico: Biochemistry; Biology, life sciences; Research & information: general
• Soggetto non controllato: aging; aging heart; assembly factor; ATP synthase; ATP synthase/hydrolase; atypical myopathy; Barth syndrome; Bcl-2 family; bioenergetics; C; cancer; cardiolipin; cardiomyopathy; cell culture; cell signaling; cellular bioenergetics; cellular signaling; complex I assembly; complex I deficiency; complex I structure; complex III; COVID-19; cristae; cytochrome b; diabetes; Dilated Cardiomyopathy with Ataxia; electron transport chain; energy metabolism; entorhinal cortex; equine primary myoblasts; exercise; fatty acid oxidation; fibroblasts; frozen tissue; G mutation; glucagon; heart failure; high-resolution respirometry; human disease; immune system; influenza; innate immune response; insulin; Leigh syndrome; leukocytes; lipoxidation-derived damage; m.3243A> m.8909T> mammalian complex I; mathematical model; MAVS; MDA5; metabolic disease; mitochondria; mitochondrial disease; mitochondrial diseases; mitochondrial DNA; mitochondrial dynamic; mitochondrial dynamics; mitochondrial dysfunction; mitochondrial permeability transition pore; mitochondrial proteostasis; MT-ATP6; MTCYB mutations; n/a; NADH dehydrogenase; nephropathy; neurodegeneration; oleate; oxidative damage; oxidative phosphorylation; oxidative stress; oxygen consumption; palmitate; pancreatic endocrine cells; pet mutants; platelets; programmed cell death; protein import; respiratory chain; respiratory complex assembly; respiratory complexes; respiratory supercomplexes; respirometry; RIG-I; ROS; RSV; Saccharomyces cerevisiae; SARS CoV-2; Sengers syndrome; skeletal muscle; supercomplexes; supernumerary subunits; toxicity assays; viral infections; yeast
• Persona (resp. second.): NesciSalvatore; LenazGiorgio
• Sommario/riassunto: Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction.
• Titolo autorizzato: Impaired Mitochondrial Bioenergetics under Pathological Conditions
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910585934503321
• Lo trovi qui: Univ. Federico II