LEADER 05234nam 2201561z- 450 001 9910585934503321 005 20220812 035 $a(CKB)5600000000483143 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91183 035 $a(oapen)doab91183 035 $a(EXLCZ)995600000000483143 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aImpaired Mitochondrial Bioenergetics under Pathological Conditions 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (460 p.) 311 08$a3-0365-4648-0 311 08$a3-0365-4647-2 330 $aMitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. 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Introduction: Affirmative ethics, wilfulness, and affects as forms -- 2. Urban wanderer and wilful performances: Head-on (Gegen die wand) -- 3. Housing wilfulness: Wadjda -- 4. Lived body, affects and cars: Friday night (Vendredi soir) -- 5. Conclusion: Affirmative aesthetics. 330 $aWhile the idea of women who stay at home and men who dominate the streets may seem outdated, binary considerations of gender, space, and power still proliferate in contemporary cinema. This open access book adopts a fluid approach to space designed to accommodate wilful, affirmative, and imaginative perspectives of gender on screen. Through close analysis, or micro-analysis, of Messidor (Alain Tanner, 1979), Vendredi Soir (Claire Denis, 2002), Wadjda (Haifaa Al-Mansour, 2012), and Head-On (Fatih Akin, 2004), this book looks for light, textures, rhythms, movement, and sound that give shape to affirmative forms, forms that contribute to rewriting bodies and spaces?such as cars, homes, and city streets?that reject traditional gender and power structures. Wilful women drive this book forward, through movement and pauses, imagination and desire, persistence and dissimulation, eroticism, performance and abjection. 606 $aMotion pictures 606 $aSex 606 $aFilm Theory 606 $aGender Studies 615 0$aMotion pictures. 615 0$aSex. 615 14$aFilm Theory. 615 24$aGender Studies. 676 $a791.4301 676 $a791.43653 686 $aPER004000$aSOC032000$2bisacsh 700 $aCeuterick$b Maud$4aut$4http://id.loc.gov/vocabulary/relators/aut$0846503 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910424948403321 996 $aAffirmative Aesthetics and Wilful Women$91891338 997 $aUNINA