LEADER 01768oam 2200517 450 001 9910711727003321 005 20190510161813.0 035 $a(CKB)5470000002486804 035 $a(OCoLC)1081334222 035 $a(EXLCZ)995470000002486804 100 $a20190110d2018 ua 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aGrid modernization of cooperatives and municipal utilities via breakthrough system monitoring, control and optimization /$fFei Ding 210 1$a[Golden, Colo.] :$cNational Renewable Energy Laboratory,$d2018. 215 $a1 online resource (14 pages) $ccolor illustrations, color maps 225 1 $aNREL/PR ;$v5D00-72745 300 $a"ADMS workshop, September 26, 2018." 606 $aElectric cooperatives$zUnited States 606 $aElectric utilities$zUnited States 606 $aSmart power grids$zUnited States 606 $aElectric cooperatives$2fast 606 $aElectric utilities$2fast 606 $aSmart power grids$2fast 607 $aUnited States$2fast 615 0$aElectric cooperatives 615 0$aElectric utilities 615 0$aSmart power grids 615 7$aElectric cooperatives. 615 7$aElectric utilities. 615 7$aSmart power grids. 700 $aDing$b Fei$f1976-$01412350 712 02$aNational Renewable Energy Laboratory (U.S.), 801 0$bGPO 801 1$bGPO 801 2$bGPO 801 2$bOCLCF 801 2$bMERUC 801 2$bGPO 906 $aBOOK 912 $a9910711727003321 996 $aGrid modernization of cooperatives and municipal utilities via breakthrough system monitoring, control and optimization$93505612 997 $aUNINA LEADER 05234nam 2201561z- 450 001 9910585934503321 005 20220812 035 $a(CKB)5600000000483143 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91183 035 $a(oapen)doab91183 035 $a(EXLCZ)995600000000483143 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aImpaired Mitochondrial Bioenergetics under Pathological Conditions 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (460 p.) 311 08$a3-0365-4648-0 311 08$a3-0365-4647-2 330 $aMitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. 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