Drug Metabolism/Transport and Pharmacokinetics

• Autore: Song Im-Sook
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Descrizione fisica: 1 online resource (232 p.)
• Soggetto topico: Manufacturing industries; Medicine and Nursing
• Soggetto non controllato: acute renal failure; anti-obesity agent; automatization; BCRP; biliary excretion; breast cancer resistance protein; Caco-2; carboxylesterase; Carthamus tinctorius extract; catalposide; celecoxib; cisplatin; comparative pharmacokinetic study; compatibility mechanism; compound K; creatinine clearance; CYP3A4; cytochrome P450; cytochrome P450 enzymes; diabetes; dose-dependent pharmacokinetics; drug absorption; drug dosing; drug interaction; drug transporter; drug-drug interaction; DWP16001; efflux transporter; EpiIntestinal; first-pass; fluorescence; food-drug interactions; gentamicin; head-and-neck cancer; healthy Korean subjects; hepatic and intestinal first-pass effect; hepatic CYP3A1(23); HPLC; HSG4112; human hepatocytes; in vitro human metabolism; influx transporter; inhibition mode; inhibitor; intestinal metabolism; kidney distribution; kinetic analysis; large volume direct injection; mertansine; metabolism; metformin; modeling; nonrenal clearance; notoginseng total saponins; oral availability; organic cation transporter 2; P-gp; pharmacokinetics; physiologically based pharmacokinetic model; population pharmacokinetic; prazosin; protopanaxadiol (PPD); quercetin; rats; real-time measurements; renal clearance; renal excretion; repaglinide; sodium-glucose cotransporter 2 (SGLT2) inhibitors; stereoselectivity; sulfasalazine; sulfotransferase; taxanes; tiropramide; tissue engineering; tofacitinib; transporter-enzyme interplay; UDP-glucuronosyltransferase; UDP-glucuronosyltransferases; UHPLC-MS/MS; verapamil
• Persona (resp. second.): SongIm-Sook
• Sommario/riassunto: This book serves to highlight the pharmacokinetics/drug-drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters.
• Titolo autorizzato: Drug Metabolism
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557607703321
• Lo trovi qui: Univ. Federico II