04569nam 2201321z- 450 991055760770332120231214133354.0(CKB)5400000000045325(oapen)https://directory.doabooks.org/handle/20.500.12854/77070(EXLCZ)99540000000004532520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDrug Metabolism/Transport and PharmacokineticsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (232 p.)3-0365-2459-2 3-0365-2458-4 This book serves to highlight the pharmacokinetics/drug–drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters.MedicinebicsscPharmaceutical industriesbicssctofacitinibdose-dependent pharmacokineticshepatic and intestinal first-pass effectratscatalposidein vitro human metabolismUDP-glucuronosyltransferasesulfotransferasecarboxylesterasecelecoxibdrug–drug interactionfluorescenceHPLCmetabolismrepaglinideHSG4112anti-obesity agentstereoselectivitypharmacokineticscompound Kprotopanaxadiol (PPD)biliary excretionintestinal metabolismCarthamus tinctorius extractnotoginseng total saponinscomparative pharmacokinetic studylarge volume direct injectioncompatibility mechanismmertansinehuman hepatocytescytochrome P450UDP-glucuronosyltransferasessodium-glucose cotransporter 2 (SGLT2) inhibitorsDWP16001kidney distributioninhibition modediabetestransporter-enzyme interplayinflux transporterefflux transporterphysiologically based pharmacokinetic modelcytochrome P450 enzymestiropramidehealthy Korean subjectsmodelingpopulation pharmacokineticquercetinbreast cancer resistance proteininhibitorprazosinsulfasalazinekinetic analysisfood–drug interactionsCaco-2EpiIntestinalfirst-passP-gpBCRPdrug transporterCYP3A4oral availabilityautomatizationdrug absorptiondrug dosinghead-and-neck cancerreal-time measurementstaxanestissue engineeringUHPLC-MS/MSmetforminverapamildrug interactionorganic cation transporter 2renal excretionacute renal failuregentamicincisplatinhepatic CYP3A1(23)creatinine clearancerenal clearancenonrenal clearanceMedicinePharmaceutical industriesSong Im-Sookedt1302990Song Im-SookothBOOK9910557607703321Drug Metabolism3038985UNINA