04602nam 2201333z- 450 991055760770332120220111(CKB)5400000000045325(oapen)https://directory.doabooks.org/handle/20.500.12854/77070(oapen)doab77070(EXLCZ)99540000000004532520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierDrug Metabolism/Transport and PharmacokineticsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (232 p.)3-0365-2459-2 3-0365-2458-4 This book serves to highlight the pharmacokinetics/drug-drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters.Manufacturing industriesbicsscMedicine and Nursingbicsscacute renal failureanti-obesity agentautomatizationBCRPbiliary excretionbreast cancer resistance proteinCaco-2carboxylesteraseCarthamus tinctorius extractcatalposidecelecoxibcisplatincomparative pharmacokinetic studycompatibility mechanismcompound Kcreatinine clearanceCYP3A4cytochrome P450cytochrome P450 enzymesdiabetesdose-dependent pharmacokineticsdrug absorptiondrug dosingdrug interactiondrug transporterdrug-drug interactionDWP16001efflux transporterEpiIntestinalfirst-passfluorescencefood-drug interactionsgentamicinhead-and-neck cancerhealthy Korean subjectshepatic and intestinal first-pass effecthepatic CYP3A1(23)HPLCHSG4112human hepatocytesin vitro human metabolisminflux transporterinhibition modeinhibitorintestinal metabolismkidney distributionkinetic analysislarge volume direct injectionmertansinemetabolismmetforminmodelingnonrenal clearancenotoginseng total saponinsoral availabilityorganic cation transporter 2P-gppharmacokineticsphysiologically based pharmacokinetic modelpopulation pharmacokineticprazosinprotopanaxadiol (PPD)quercetinratsreal-time measurementsrenal clearancerenal excretionrepaglinidesodium-glucose cotransporter 2 (SGLT2) inhibitorsstereoselectivitysulfasalazinesulfotransferasetaxanestiropramidetissue engineeringtofacitinibtransporter-enzyme interplayUDP-glucuronosyltransferaseUDP-glucuronosyltransferasesUHPLC-MS/MSverapamilManufacturing industriesMedicine and NursingSong Im-Sookedt1302990Song Im-SookothBOOK9910557607703321Drug Metabolism3038985UNINA