Colorectal Cancers: From Present Problems to Future Solutions

• Autore: Allgayer Heike
• Pubblicazione: Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022
• Descrizione fisica: 1 online resource (238 p.)
• Soggetto topico: Medicine and Nursing; Oncology
• Soggetto non controllato: (molecular) carcinogenesis; (single) cancer cell heterogeneity; (targeted) therapy; bacteriophages; biomarker; blood values; bovine meat and milk factors (BMMF); cancer; cancer progression; CellSearch® system; chromatin density; chronic zoonosis; circulating tumor cells; cohort; colon cancer; colorectal; colorectal cancer; comparative oncology; CTNNB1; deposited energy; diet; DKK1; DNA double-strand breaks; drug combinations; early onset; epidemiology; EPISPOT assay; gender; genome-wide methylation array; immune landscape; indirect carcinogenesis; infection; infectious agents; liquid biopsy; Matrix Metalloproteinases (MMPs); metastasis; methylation; microRNAs; miRNA; MMP polymorphisms; MMP targeting; models; multiplex; nanoscale; nutrition; patient survival; personalized medicine; personalized treatment; Phage; polyp; predictive value; quality of life; radiochemotherapy; radiosensitivity; rectal cancer; S100A4; spontaneous feline intestinal tumors; super-resolution microscopy; TIMPs; tumor budding; tumor immunology; tumour cell heterogeneity; Wnt signaling
• Persona (resp. second.): AllgayerHeike
• Sommario/riassunto: The scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repair, cellular aging, signaling cascades, genomic, epigenetic, transcriptional, translational, and protein modifications, as well as microbiotic factors and further parameters. Progression and metastasis have been more intensively studied, especially during recent years, leading to an intensified knowledge on molecular protagonists and microenvironmental interactions contributing to invasion, dissemination, and metastasis; still, more concerted efforts need to be made to better understand issues such as metastasis to different sites or the metastatic heterogeneity of single cells. Nevertheless, based on actual discoveries, personalized medicine, together with highly interdisciplinary therapeutic strategies combining advanced levels of surgical techniques, oncology, and radiation in neoadjuvant, adjuvant, or palliative settings, has started to improve the clinical prognosis of individual patients with colorectal cancer. The present Special Issue features articles of excellent international experts with the latest data in the fields mentioned. With this Special Issue, we aim to deepen discussions amongst colleagues in all kinds of disciplines working on this disease and to intensify interdisciplinary collaborations aimed at an ultimate understanding of strategies to defeat and prevent, colorectal cancer, and its progression.
• Altri titoli varianti: Colorectal Cancers
• Titolo autorizzato: Colorectal Cancers: From Present Problems to Future Solutions
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910585937103321
• Lo trovi qui: Univ. Federico II