LEADER 04826nam 2201129z- 450 001 9910585937103321 005 20220812 035 $a(CKB)5600000000483111 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/91155 035 $a(oapen)doab91155 035 $a(EXLCZ)995600000000483111 100 $a20202208d2022 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aColorectal Cancers: From Present Problems to Future Solutions 210 $aBasel$cMDPI - Multidisciplinary Digital Publishing Institute$d2022 215 $a1 online resource (238 p.) 311 08$a3-0365-4727-4 311 08$a3-0365-4728-2 330 $aThe scientific community has made significant progress in our molecular understanding of sporadic and hereditary colorectal carcinogenesis and progression. Thie pertains to, e.g., the discovery of (mutated) oncogenes and tumor suppressor genes, microsatellite instabilities, modifications in DNA repair, cellular aging, signaling cascades, genomic, epigenetic, transcriptional, translational, and protein modifications, as well as microbiotic factors and further parameters. Progression and metastasis have been more intensively studied, especially during recent years, leading to an intensified knowledge on molecular protagonists and microenvironmental interactions contributing to invasion, dissemination, and metastasis; still, more concerted efforts need to be made to better understand issues such as metastasis to different sites or the metastatic heterogeneity of single cells. Nevertheless, based on actual discoveries, personalized medicine, together with highly interdisciplinary therapeutic strategies combining advanced levels of surgical techniques, oncology, and radiation in neoadjuvant, adjuvant, or palliative settings, has started to improve the clinical prognosis of individual patients with colorectal cancer. The present Special Issue features articles of excellent international experts with the latest data in the fields mentioned. With this Special Issue, we aim to deepen discussions amongst colleagues in all kinds of disciplines working on this disease and to intensify interdisciplinary collaborations aimed at an ultimate understanding of strategies to defeat and prevent, colorectal cancer, and its progression. 517 $aColorectal Cancers 606 $aMedicine and Nursing$2bicssc 606 $aOncology$2bicssc 610 $a(molecular) carcinogenesis 610 $a(single) cancer cell heterogeneity 610 $a(targeted) therapy 610 $abacteriophages 610 $abiomarker 610 $ablood values 610 $abovine meat and milk factors (BMMF) 610 $acancer 610 $acancer progression 610 $aCellSearch® system 610 $achromatin density 610 $achronic zoonosis 610 $acirculating tumor cells 610 $acohort 610 $acolon cancer 610 $acolorectal 610 $acolorectal cancer 610 $acomparative oncology 610 $aCTNNB1 610 $adeposited energy 610 $adiet 610 $aDKK1 610 $aDNA double-strand breaks 610 $adrug combinations 610 $aearly onset 610 $aepidemiology 610 $aEPISPOT assay 610 $agender 610 $agenome-wide methylation array 610 $aimmune landscape 610 $aindirect carcinogenesis 610 $ainfection 610 $ainfectious agents 610 $aliquid biopsy 610 $aMatrix Metalloproteinases (MMPs) 610 $ametastasis 610 $amethylation 610 $amicroRNAs 610 $amiRNA 610 $aMMP polymorphisms 610 $aMMP targeting 610 $amodels 610 $amultiplex 610 $ananoscale 610 $anutrition 610 $apatient survival 610 $apersonalized medicine 610 $apersonalized treatment 610 $aPhage 610 $apolyp 610 $apredictive value 610 $aquality of life 610 $aradiochemotherapy 610 $aradiosensitivity 610 $arectal cancer 610 $aS100A4 610 $aspontaneous feline intestinal tumors 610 $asuper-resolution microscopy 610 $aTIMPs 610 $atumor budding 610 $atumor immunology 610 $atumour cell heterogeneity 610 $aWnt signaling 615 7$aMedicine and Nursing 615 7$aOncology 700 $aAllgayer$b Heike$4edt$01314126 702 $aAllgayer$b Heike$4oth 906 $aBOOK 912 $a9910585937103321 996 $aColorectal Cancers: From Present Problems to Future Solutions$93031737 997 $aUNINA