Toxin-Antitoxin Systems in Pathogenic Bacteria

• Autore: Alonso Juan Carlos
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021
• Descrizione fisica: 1 electronic resource (170 p.)
• Soggetto topico: Medicine
• Soggetto non controllato: tuberculosis; toxin-antitoxin systems; bacterial cell death; NAD+; stress-response; toxin-antitoxin system; mazF; type II; toxin; mRNA interferase; X-ray crystallography; cognate interactions; cross-interactions; molecular insulation; antitoxin; TA systems; addiction; anti-addiction; type I toxin-antitoxin system; small protein toxin structure; Fst/Ldr family; toxin-antitoxin; M. tuberculosis; bacteria; pathogenesis; protein-protein interactions; cross-talk; protein interface; tolerance; persistence; cross-resistance; PemI/PemK; Klebsiella pneumoniae; toxin activation; antibacterial agents; bacterial persistence; Stenotrophomonas maltophilia; opportunistic pathogen; clinical origin; environmental origin; biofilm; antibiotic resistance; cell wall inhibition; nucleotide hydrolysis; uridine diphosphate-N-acetylglucosamine
• Persona (resp. second.): AlonsoJuan Carlos
• Sommario/riassunto: Bacterial toxin–antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens.
• Titolo autorizzato: Toxin-Antitoxin Systems in Pathogenic Bacteria
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910674020103321
• Lo trovi qui: Univ. Federico II