01028nam0-2200337li-450 99000016584020331620180312154742.00-201-62767-10016584USA010016584(ALEPH)000016584USA01001658420001109d1993----km-y0itay0103----baengGBObject-Oriented software engineeringthe professional developer's guideGeorge WilkieWokingham [etc.]Addison-Wesley,copyr. 1993programmazione oggetto-orientata005.1.Wilkie,George753482Sistema bibliotecario di Ateneo dell' Università di SalernoRICA990000165840203316005.1 WIL0006737BKTEC1996021520001110USA01171220020403USA011624PATRY9020040406USA011612Object-Oriented software engineering1515750UNISA04227nam 2200913z- 450 991067402010332120220111(CKB)5400000000042053(oapen)https://directory.doabooks.org/handle/20.500.12854/76444(oapen)doab76444(EXLCZ)99540000000004205320202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierToxin-Antitoxin Systems in Pathogenic BacteriaBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (170 p.)3-0365-0674-8 3-0365-0675-6 Bacterial toxin-antitoxin (TA) systems, which are ubiquitously present in bacterial genomes, are not essential for normal cell proliferation. The TA systems regulate fundamental cellular processes, facilitate survival under stress conditions, have essential roles in virulence and represent potential therapeutic targets. These genetic TA loci are also shown to be involved in the maintenance of successful multidrug-resistant mobile genetic elements. The TA systems are classified as types I to VI, according to the nature of the antitoxin and to the mode of toxin inhibition. Type II TA systems encode a labile antitoxin and its stable toxin; degradation of the antitoxin renders a free toxin, which is bacteriostatic by nature. A free toxin generates a reversible state with low metabolic activity (quiescence) by affecting important functions of bacterial cells such as transcription, translation, DNA replication, replication and cell-wall synthesis, biofilm formation, phage predation, the regulation of nucleotide pool, etc., whereas antitoxins are toxin inhibitors. Under stress conditions, the TA systems might form networks. To understand the basis of the unique response of TA systems to stress, the prime causes of the emergence of drug-resistant strains, and their contribution to therapy failure and the development of chronic and recurrent infections, must be known in order to grasp how TA systems contribute to the mechanisms of phenotypic heterogeneity and pathogenesis that will enable the rational development of new treatments for infections caused by pathogens.Medicinebicsscaddictionanti-addictionantibacterial agentsantibiotic resistanceantitoxinbacteriabacterial cell deathbacterial persistencebiofilmcell wall inhibitionclinical origincognate interactionscross-interactionscross-resistancecross-talkenvironmental originFst/Ldr familyKlebsiella pneumoniaeM. tuberculosismazFmolecular insulationmRNA interferasen/aNAD+nucleotide hydrolysisopportunistic pathogenpathogenesisPemI/PemKpersistenceprotein interfaceprotein-protein interactionssmall protein toxin structureStenotrophomonas maltophiliastress-responseTA systemstolerancetoxintoxin activationtoxin-antitoxintoxin-antitoxin systemtoxin-antitoxin systemtoxin-antitoxin systemstoxin-antitoxin systemstuberculosistype I toxin-antitoxin systemtype IIuridine diphosphate-N-acetylglucosamineX-ray crystallographyMedicineAlonso Juan Carlosedt1339342Alonso Juan CarlosothBOOK9910674020103321Toxin-Antitoxin Systems in Pathogenic Bacteria3060081UNINA02407nam0 22004693i 450 RMS155948620251003044345.00471651281cloth978047165128420060523d2006 ||||0itac50 baengusz01i xxxe z01nˆA ‰basic introduction to pollutant fate and transportan integrated approach with chemistry, modeling, risk assessment, and environmental legislationFrank M. DunnivantElliot AndersHobokenWiley-Interscience, a John Wiley & Sons publication©2006XXII, 480 p.1 CD-ROM ; 24 cm. In cop.: With the pC-pH simulator, the pollutant fate and transport simulator fate®Professor of Pure Mathematics, University of Cambridge, United KingdomMILV022915Whitman College, Walla Walla, Washington DC, U.S.A.RMSV639438Educational Solutions, Mohawk Trail Reg. Sch. Distr., Shelburne Falls, U.S.A.RMSV639440Chemist, Washington DC, U.S.A.UTOV505877Professor, Environmental Chemistry, Clemson University, South Carolina, U.S.A.UTOV505880Subsurface Sc. Group, Env. Sc. Div., Oak Ridge National laboratory, TN, U.S.A.UTOV505881Institut für Biogeochemie und Schadstoffdynamik, ETH Zürich, SwitzerlandUTOV505882Tecnologia del controllo dell'inquinamentoFIRNAPC221003I628.5TECNOLOGIA DEL CONTROLLO DELL'INQUINAMENTO E INGEGNERIA SANITARIA INDUSTRIALE14Dunnivant, Frank M.RMSV639438070448177Anders, ElliotRMSV639440070448178Coates, John <matematico>MILV022915280McLean, LorettaUTOV505877280Elzerman, AlanUTOV505880280Jardine, PhilipUTOV505881280Schwarzenback, René P.UTOV505882280ITIT-00000020060523IT-BN0095 NAP 01SALA $RMS1559486Biblioteca Centralizzata di Ateneo1 v. 01SALA 628.5 DUN.ba 0104 0000007955 VMA 1 v.A 2007111620071116 01Basic introduction to pollutant fate and transport108678UNISANNIO