Autophagy in Tissue Injury and Homeostasis

• Autore: Lin Pei-Hui
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
• Descrizione fisica: 1 online resource (322 p.)
• Soggetto topico: Medicine and Nursing
• Soggetto non controllato: acute kidney injury; acute lung injury; aging; AMPK; apoptosis; ATGs; autophagic flux; autophagy; Autophagy; Beclin-1; biomarkers; caloric restriction; cardiac dysfunction; cell death; cirrhosis; COPD; Crohn's disease; cystic fibrosis; diabetic nephropathy; diabetic retinopathy; dietary restriction; endotoxemia; ethanol; exercise; exosomes; fibrosis; FOXO; glutaminase; HCC therapy; hepatic stellate cells; hepatocellular carcinoma; hepatocytes; idiopathic pulmonary fibrosis; immune; immune cell; infertility; inflammasome; inflammation; inflammatory bowel disease; inflammatory bowel diseases; innate immunity; intestinal homeostasis; ischemia; kidney diseases; LC3; lysosomal damage; macrophage; macrophages; metabolism; mitochondria; mitophagy; molecular rehabilitation; mTOR; MTOR; muscle regeneration; n/a; neuronal cell death; Notoginsenoside R1; oxidative stress; PAH; Paneth cell; parkin; Parkin; PINK1; renal tubular cells; senescence; sepsis; Sertoli cell; sinusoidal endothelial cells; spinal cord injury; stem cell; TFEB; traumatic brain injury; tuberculosis
• Persona (resp. second.): LinPei-Hui
• Sommario/riassunto: Autophagy ("auto-digestion"), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of organelles (mitochondria and others). Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still emerging. In this Special Issue on "Autophagy in Tissue Injury and Homeostasis", we focus on the roles of autophagy in systemic, specific tissue (organs/cells) injury or organ failure associated with sepsis, inflammation, metabolic disorder, toxic chemicals, ischemia-reperfusion injury, hypoxic oxidative stress, tissue fibrosis, trauma, and nutrient starvation. The knowledge gained from the identification and characterization of new molecular mechanisms will shed light on biomedical applications for tissue protection through the modulation of autophagy.
• Titolo autorizzato: Autophagy in Tissue Injury and Homeostasis
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557284203321
• Lo trovi qui: Univ. Federico II