LEADER 04262nam 2201225z- 450 001 9910557284203321 005 20210501 035 $a(CKB)5400000000041198 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/69422 035 $a(oapen)doab69422 035 $a(EXLCZ)995400000000041198 100 $a20202105d2020 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAutophagy in Tissue Injury and Homeostasis 210 $aBasel, Switzerland$cMDPI - Multidisciplinary Digital Publishing Institute$d2020 215 $a1 online resource (322 p.) 311 08$a3-03943-781-X 311 08$a3-03943-782-8 330 $aAutophagy ("auto-digestion"), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of organelles (mitochondria and others). Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still emerging. In this Special Issue on "Autophagy in Tissue Injury and Homeostasis", we focus on the roles of autophagy in systemic, specific tissue (organs/cells) injury or organ failure associated with sepsis, inflammation, metabolic disorder, toxic chemicals, ischemia-reperfusion injury, hypoxic oxidative stress, tissue fibrosis, trauma, and nutrient starvation. The knowledge gained from the identification and characterization of new molecular mechanisms will shed light on biomedical applications for tissue protection through the modulation of autophagy. 606 $aMedicine and Nursing$2bicssc 610 $aacute kidney injury 610 $aacute lung injury 610 $aaging 610 $aAMPK 610 $aapoptosis 610 $aATGs 610 $aautophagic flux 610 $aautophagy 610 $aAutophagy 610 $aBeclin-1 610 $abiomarkers 610 $acaloric restriction 610 $acardiac dysfunction 610 $acell death 610 $acirrhosis 610 $aCOPD 610 $aCrohn's disease 610 $acystic fibrosis 610 $adiabetic nephropathy 610 $adiabetic retinopathy 610 $adietary restriction 610 $aendotoxemia 610 $aethanol 610 $aexercise 610 $aexosomes 610 $afibrosis 610 $aFOXO 610 $aglutaminase 610 $aHCC therapy 610 $ahepatic stellate cells 610 $ahepatocellular carcinoma 610 $ahepatocytes 610 $aidiopathic pulmonary fibrosis 610 $aimmune 610 $aimmune cell 610 $ainfertility 610 $ainflammasome 610 $ainflammation 610 $ainflammatory bowel disease 610 $ainflammatory bowel diseases 610 $ainnate immunity 610 $aintestinal homeostasis 610 $aischemia 610 $akidney diseases 610 $aLC3 610 $alysosomal damage 610 $amacrophage 610 $amacrophages 610 $ametabolism 610 $amitochondria 610 $amitophagy 610 $amolecular rehabilitation. 610 $amTOR 610 $aMTOR 610 $amuscle regeneration 610 $an/a 610 $aneuronal cell death 610 $aNotoginsenoside R1 610 $aoxidative stress 610 $aPAH 610 $aPaneth cell 610 $aparkin 610 $aParkin 610 $aPINK1 610 $arenal tubular cells 610 $asenescence 610 $asepsis 610 $aSertoli cell 610 $asinusoidal endothelial cells 610 $aspinal cord injury 610 $astem cell 610 $aTFEB 610 $atraumatic brain injury 610 $atuberculosis 615 7$aMedicine and Nursing 700 $aLin$b Pei-Hui$4edt$01324783 702 $aLin$b Pei-Hui$4oth 906 $aBOOK 912 $a9910557284203321 996 $aAutophagy in Tissue Injury and Homeostasis$93036294 997 $aUNINA