Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases

• Autore: Tikkanen Ritva
• Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
• Descrizione fisica: 1 electronic resource (276 p.)
• Soggetto topico: Research & information: general; Biology, life sciences
• Soggetto non controllato: Rabdosia inflexa; inflammation; gastric ulcer; cytokines; MAPK; NF-κB; extracellular signal-regulated kinases 1/2; hyperoxia; bronchopulmonary dysplasia; HPAECs; angiogenesis; cell cycle; SIRT1; oxidative stress; psoriasis; antimicrobial peptide; cecropin A; tight junction protein; MEK/ERK signaling; porcine intestinal epithelial cell; extracellular signal-regulated kinase 5 (ERK5); Kv4.2; PC12 cells; infantile myofibromatosis; receptor tyrosine kinases; platelet-derived growth factor receptor; protein kinase inhibitors; sunitinib; erlotinib; FR180204; U0126; targeted therapy; apoptosis; ERK1/2; JNKs; mitochondrial dysfunction; neurodegeneration; neuro-inflammation; p38 MAPKs; Parkinson's disease; mitogen-activated protein kinases (MAPKs); MAPK kinetics; osteoclast differentiation; bone remodeling; DAPK; ERK; p38; JNK; mitogen-activated protein kinase pathway (MAPK pathway); protein tyrosine phosphatase interacting protein 51 (PTPIP51); protein-protein interaction (PPI); cancer signaling; SR; CR; Compatibility; T2DM; metabolic profiling; MAPK/PI3K/Akt signaling pathway; reactive oxygen species; PTPN6; SRC; DOK4; MKK4; MKK7; p53; DUSP1; SIRT2; atherosclerosis; aortic valve sclerosis; aortic valve stenosis; naphthalimide-metal complex conjugates; N-heterocyclic carbene; mitochondria; ROS; p38 MAPK; cancer; FGF-induced signaling; FRS2; phosphorylation; downregulation
• Persona (resp. second.): Nikolic-PatersonDavid; TikkanenRitva
• Sommario/riassunto: Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.
• Altri titoli varianti: Mitogen Activated Protein Kinases
• Titolo autorizzato: Mitogen Activated Protein Kinases
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910557405603321
• Lo trovi qui: Univ. Federico II