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Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor



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Autore: Holzmann Klaus Visualizza persona
Titolo: Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor Visualizza cluster
Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
Descrizione fisica: 1 electronic resource (276 p.)
Soggetto topico: Medicine
Soggetto non controllato: FGFR4
FGF19
gene regulation
cancer signaling
anticancer
FRS2
FGFR
NVP-BGJ398
LY2874455
sarcoma
cancer-associated fibroblasts
GPER
breast cancer
estrogen
FGFR1
FGF2
optogenetics
ERK
AKT
receptor kinase
neurite outgrowth
HEK293
PC12
fibroblast growth factor receptors
signaling
receptor cross-talk
coreceptor
membrane proteins
FGFR2
ERK1/2
phosphorylation
serine
negative feedback loop
cancer
prognosis
HCC
inhibitors
FGF
fibroblast growth factor
autocrine signaling
skin
melanoma
squamous and basal cell carcinoma
seborrheic keratosis
targeted therapy
resistance
structure
kinase inhibitor
gastric cancer
monoclonal antibody
small molecule
FGFR2c
autophagy
keratinocyte
MTOR
JNK1
review
malignant glioma
brain cancer
astrocytoma
Sprouty proteins
FGF-mediated signaling
tumor suppressor
tumor promoter
malignant pleural mesothelioma
overall survival
immunohistochemistry
infigratinib sensitivity
FGF8
FGF18
adenocarcinoma of the esophagogastric junction
neoadjuvant therapy
Persona (resp. second.): MarianBrigitte
HolzmannKlaus
Sommario/riassunto: Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a high growth potential, resistance to apoptosis, neoangiogenesis and metastasis, all essential parameters relevant for tumor progression. This makes FGFs, and their tyrosine kinase receptors FGFRs, valuable targets for therapeutic interventions. This book is a collection of 15 recent articles—both original work and reviews—that summarize the current research state effectively. The content covers FGF signaling aspects in gastric, skin, liver, esophageal cancer, melanoma, mesothelioma and glioblastoma, including one article that addresses the role of FGF in the tumor-microenvironment cross-talk. Several reports describe the development of compounds targeting FGFRs, their structure and interaction with the receptor molecules, and their effectivity in preclinical and clinical testing. In summary, the papers demonstrate the complexity of the topic, with various FGF ligands and receptors involved and the need for further research. They also present results that fuel hope that targeting cancer with dysfunctional FGF signaling can become a realistic treatment option.
Altri titoli varianti: Fibroblast Growth Factor Receptor
Titolo autorizzato: Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor  Visualizza cluster
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910557898903321
Lo trovi qui: Univ. Federico II
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