04686nam 2201225z- 450 991055789890332120231214132820.0(CKB)5400000000046291(oapen)https://directory.doabooks.org/handle/20.500.12854/69010(EXLCZ)99540000000004629120202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierFibroblast Growth Factor Receptor (FGFR) Signaling Pathway in TumorBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (276 p.)3-03936-784-6 3-03936-785-4 Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a high growth potential, resistance to apoptosis, neoangiogenesis and metastasis, all essential parameters relevant for tumor progression. This makes FGFs, and their tyrosine kinase receptors FGFRs, valuable targets for therapeutic interventions. This book is a collection of 15 recent articles—both original work and reviews—that summarize the current research state effectively. The content covers FGF signaling aspects in gastric, skin, liver, esophageal cancer, melanoma, mesothelioma and glioblastoma, including one article that addresses the role of FGF in the tumor-microenvironment cross-talk. Several reports describe the development of compounds targeting FGFRs, their structure and interaction with the receptor molecules, and their effectivity in preclinical and clinical testing. In summary, the papers demonstrate the complexity of the topic, with various FGF ligands and receptors involved and the need for further research. They also present results that fuel hope that targeting cancer with dysfunctional FGF signaling can become a realistic treatment option.Fibroblast Growth Factor Receptor MedicinebicsscFGFR4FGF19gene regulationcancer signalinganticancerFRS2FGFRNVP-BGJ398LY2874455sarcomacancer-associated fibroblastsGPERbreast cancerestrogenFGFR1FGF2optogeneticsERKAKTreceptor kinaseneurite outgrowthHEK293PC12fibroblast growth factor receptorssignalingreceptor cross-talkcoreceptormembrane proteinsFGFR2ERK1/2phosphorylationserinenegative feedback loopcancerprognosisHCCinhibitorsFGFfibroblast growth factorautocrine signalingskinmelanomasquamous and basal cell carcinomaseborrheic keratosistargeted therapyresistancestructurekinase inhibitorgastric cancermonoclonal antibodysmall moleculeFGFR2cautophagykeratinocyteMTORJNK1reviewmalignant gliomabrain cancerastrocytomaSprouty proteinsFGF-mediated signalingtumor suppressortumor promotermalignant pleural mesotheliomaoverall survivalimmunohistochemistryinfigratinib sensitivityFGF8FGF18adenocarcinoma of the esophagogastric junctionneoadjuvant therapyMedicineHolzmann Klausedt1295512Marian BrigitteedtHolzmann KlausothMarian BrigitteothBOOK9910557898903321Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor3023558UNINA