Multistep continuous flow synthesis of fine chemicals with heterogeneous catalysts / / Yuki Saito

• Autore: Saito Yuki
• Pubblicazione: Singapore : , : Springer, , [2022]; ©2022
• Descrizione fisica: 1 online resource (187 pages)
• Disciplina: 543.22
• Soggetto topico: Flow chemistry; Heterogeneous catalysis
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Intro -- Supervisor's Foreword -- Abstract -- Introduction -- Synthesis of Nitro-Containing Compounds Through Multistep Continuous Flow -- Anion Exchange Resins as Catalysts for Direct Aldol-Type Reactions -- Polysilane-Supported Pd Catalysts for Continuous-Flow Hydrogenations -- Aldol-Type Reactions and Hydrogenations-Mediated Continuous-Flow Synthesis of APIs -- Conclusion -- Acknowledgement -- Contents -- Abbreviations -- 1 Introduction and Strategy -- 1.1 Continuous-Flow Synthesis -- 1.2 Four Types of Flow Reactions -- 1.3 Continuous-Flow Reactions Using Heterogeneous Catalysts (Type IV) -- 1.4 Multistep Continuous-Flow Synthesis of Fine Chemicals -- 1.5 Aldol-Hydrogenation Strategy -- References -- 2 Synthesis of Nitro-Containing Compounds Through Multistep Continuous Flow with Heterogeneous Catalysts -- 2.1 Background -- 2.2 Nitroalkene Synthesis from Nitromethane and Aldehydes -- 2.3 Metal Oxide-Catalyzed Conjugate Additions to Nitroalkenes -- 2.4 Solid Acid-Catalyzed Nucleophilic Addition of Indole -- 2.5 Silica Immobilized DMAP Catalyzed Morita-Baylis-Hillman Reaction -- 2.6 Polystyrene Immobilized Peptide Catalyzed Conjugate Addition of Aldehyde -- 2.7 Silica Immobilized Secondary Amine Catalyzed Intermolecular Cyclization with Dithiane -- 2.8 Three-Step Transformation of Nitrocompounds -- 2.9 Conclusion -- References -- 3 Polysilane-Supported Pd Catalysts for Continuous-Flow Hydrogenations -- 3.1 Background -- 3.2 Preparation of Polysilane-Supported Pd/SiO2 Catalysts -- 3.3 Hydrogenation of Decane Nitrile Using DMPSi-Pd/SiO2 Under Continuous-Flow Conditions -- 3.4 Substrate Scope for Aliphatic and Benzyl Nitriles -- 3.5 Optimization for Aromatic Nitriles -- 3.6 Substrate Scope for Aromatic Nitriles -- 3.7 Lifetime and Reaching Experiments -- 3.8 Control Experiments -- 3.9 Optimization for Hydrogenation Nitrocompounds. ; 3.10 Substrate Scope for Hydrogenation Nitrocompounds -- 3.11 Modification of Catalyst Preparation -- 3.12 Hydrogenation of Ketimine -- 3.13 Hydrogenation of Ketimine Under Continuous Flow Conditions -- 3.14 Substrate Generality of PhMePSi-[Pd/SiO2] -- 3.15 Summary -- References -- 4 Anion Exchange Resins as Catalysts for Direct Aldol-Type Reactions of Ketones, Esters, and Nitriles Under Continuous-Flow Conditions -- 4.1 Background -- 4.2 Aldol-Type Reactions with Ketone Under Batch Conditions -- 4.3 Aldol-Type Reactions with Ketone Under Flow Conditions -- 4.4 Reinvestigation of Aldol Reaction with Ketone Under Batch Conditions -- 4.5 Aldol Reaction with α-Aryl Ester Under Batch Conditions -- 4.6 Aldol Reaction with Nitriles with Ethoxide Resin -- 4.7 Summary -- References -- 5 Multistep Continuous-Flow Synthesis of APIs Based on Aldol-Hydrogenation Strategy -- 5.1 Background -- 5.2 Flow Synthesis of Venlafaxine -- 5.3 Flow Synthesis of Donepezil -- 5.4 Summary -- References -- Summary -- Experimental Section-Chapter 2 -- Experimental Section-Chapter 3 -- Experimental Section-Chapter 4 -- Experimental Section-Chapter 5.
• Titolo autorizzato: Multistep Continuous Flow Synthesis of Fine Chemicals with Heterogeneous Catalysts
• ISBN: 9789811972584; 9789811972577
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910633928303321
• Lo trovi qui: Univ. Federico II
• Serie: Springer theses.