LEADER 03598nam 22006495 450 001 9910633928303321 005 20251008133621.0 010 $a9789811972584$b(electronic bk.) 010 $z9789811972577 024 7 $a10.1007/978-981-19-7258-4 035 $a(MiAaPQ)EBC7150353 035 $a(Au-PeEL)EBL7150353 035 $a(CKB)25504309300041 035 $a(PPN)266350607 035 $a(DE-He213)978-981-19-7258-4 035 $a(OCoLC)1352416120 035 $a(EXLCZ)9925504309300041 100 $a20221130d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMultistep Continuous Flow Synthesis of Fine Chemicals with Heterogeneous Catalysts /$fby Yuki Saito 205 $a1st ed. 2023. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2023. 215 $a1 online resource (187 pages) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 311 08$aPrint version: Saito, Yuki Multistep Continuous Flow Synthesis of Fine Chemicals with Heterogeneous Catalysts Singapore : Springer,c2023 9789811972577 320 $aIncludes bibliographical references. 327 $a1. Introduction and Strategy -- 2. Synthesis of Nitro-containing Compounds through Multistep Continuous-flow with Heterogeneous Catalysts -- 3. Polysilane-Supported Pd Catalysts for Continuous-flow Hydrogenations -- 4. Anion Exchange Resins as Catalysts for Direct Aldol-type Reactions of Ketones, Esters and Nitriles under Continuous-flow -- 5. Multistep Continuous-flow Synthesis of APIs Based on Aldol-hydrogenation Strategy -- 6. Summary -- 7. Experimental Section. 330 $aThis book describes the development of two kinds of continuous-flow transformation using heterogeneous catalysts, and explains how they can be applied in the multistep synthesis of active pharmaceutical ingredients. It demonstrates and proves that fine chemicals can be synthesized under continuous-flow conditions using heterogeneous catalysis alone. Importantly, the book also proposes a general concept and strategy for achieving multistep flow synthesis and developing heterogeneous catalysts, and shows that commercially available anion exchange resin can be used as a water-tolerant strong base catalyst for various types of continuous-flow aldol-type reaction. Reviewing the state of the art in heterogeneous catalysis in flow chemistry ? a ?hot topic? and rapidly developing area of organic synthesis ? the book will provide readers with a deeper understanding of fine chemical flow synthesis and its future prospects. . 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5061 606 $aCatalysis 606 $aOrganometallic chemistry 606 $aGreen chemistry 606 $aChemistry, Technical 606 $aCatalysis 606 $aOrganometallic Chemistry 606 $aGreen Chemistry 606 $aIndustrial Chemistry 615 0$aCatalysis. 615 0$aOrganometallic chemistry. 615 0$aGreen chemistry. 615 0$aChemistry, Technical. 615 14$aCatalysis. 615 24$aOrganometallic Chemistry. 615 24$aGreen Chemistry. 615 24$aIndustrial Chemistry. 676 $a543.22 700 $aSaito$b Yuki$01271290 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910633928303321 996 $aMultistep Continuous Flow Synthesis of Fine Chemicals with Heterogeneous Catalysts$92994678 997 $aUNINA