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Mammalian Sterols : Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids / / edited by Damjana Rozman, Rolf Gebhardt



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Titolo: Mammalian Sterols : Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids / / edited by Damjana Rozman, Rolf Gebhardt Visualizza cluster
Pubblicazione: Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020
Edizione: 1st ed. 2020.
Descrizione fisica: 1 online resource (V, 171 p. 57 illus., 14 illus. in color.)
Disciplina: 612.01577
Soggetto topico: Molecular biology
Biochemistry
Hepatology
Lipids
Metabolism
Human genetics
Molecular Medicine
Animal Biochemistry
Lipidology
Metabolomics
Human Genetics
Esteroides
Mamífers
Soggetto genere / forma: Llibres electrònics
Persona (resp. second.): RozmanDamjana
GebhardtRolf
Nota di contenuto: Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
Sommario/riassunto: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
Titolo autorizzato: Mammalian Sterols  Visualizza cluster
ISBN: 3-030-39684-3
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910416100803321
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