LEADER 04159nam  22007575  450 
001 9910416100803321
005 20220520130119.0
010   $a3-030-39684-3
024 7 $a10.1007/978-3-030-39684-8
035   $a(CKB)4100000011384298
035   $a(DE-He213)978-3-030-39684-8
035   $a(MiAaPQ)EBC6301093
035   $a(PPN)250216507
035   $a(EXLCZ)994100000011384298
100   $a20200810d2020      u|         0
101 0 $aeng
135   $aurnn#008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aMammalian Sterols $eNovel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids /$fedited by Damjana Rozman, Rolf Gebhardt
205   $a1st ed. 2020.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2020.
215   $a1 online resource (V, 171 p. 57 illus., 14 illus. in color.)
311   $a3-030-39683-5 
327   $aSterols from the post-lanosterol part of cholesterol synthesis ? novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
330   $aThis book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
606   $aMolecular biology
606   $aBiochemistry
606   $aHepatology
606   $aLipids
606   $aMetabolism
606   $aHuman genetics
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
606   $aAnimal Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14013
606   $aHepatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33088
606   $aLipidology$3https://scigraph.springernature.com/ontologies/product-market-codes/L14080
606   $aMetabolomics$3https://scigraph.springernature.com/ontologies/product-market-codes/L15030
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
606   $aEsteroides$2thub
606   $aMamífers$2thub
608   $aLlibres electrònics$2thub
615  0$aMolecular biology.
615  0$aBiochemistry.
615  0$aHepatology.
615  0$aLipids.
615  0$aMetabolism.
615  0$aHuman genetics.
615 14$aMolecular Medicine.
615 24$aAnimal Biochemistry.
615 24$aHepatology.
615 24$aLipidology.
615 24$aMetabolomics.
615 24$aHuman Genetics.
615  7$aEsteroides
615  7$aMamífers
676   $a612.01577
702   $aRozman$b Damjana$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aGebhardt$b Rolf$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910416100803321
996   $aMammalian Sterols$92250473
997   $aUNINA