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New edge of antibiotic development : antimicrobial peptides and corresponding resistance / / topic editors: Nádia S. Parachin and Octavio L. Franco



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Autore: Nadia S. Parachin Visualizza persona
Titolo: New edge of antibiotic development : antimicrobial peptides and corresponding resistance / / topic editors: Nádia S. Parachin and Octavio L. Franco Visualizza cluster
Pubblicazione: Frontiers Media SA, 2014
France : , : Frontiers Media SA, , 2014
Descrizione fisica: 1 online resource (144 pages) : illustrations (colour); digital file(s)
Soggetto topico: Pharmacy, Therapeutics, & Pharmacology
Health & Biological Sciences
Soggetto non controllato: pathogenic bacteria
Fungi
natural
peptide design
proteinase inhibitors
Bacterial resistance
virus
antimicrobial peptides
self-assembled structures
Persona (resp. second.): FrancoOctavio L
ParachinNádia S
Note generali: Bibliographic Level Mode of Issuance: Monograph
Nota di bibliografia: Includes bibliographical references.
Sommario/riassunto: Increased pathogen resistance to conventional drugs is partially due to increased numbers of immune-compromised patients, therefore the development of alternative antibiotic therapies able to circumvent this problem is one of the intriguing challenges of modern medicine. The discovery of antimicrobial peptides has been considered, in recent years, to be essential for the solution to infections caused by bacterial and fungal diseases, owing to their commonly observed and naturally occurring resistance against pathogens. In addition to the obvious antimicrobial activity commonly associated with membrane disruption, such peptides also have shown auxiliary activities such as immunomodulatory, anti-tumor and biofilm-disruption. Moreover, antibiotic peptides have been considered critical as therapeutic agents for the control of infectious bacterial diseases; the resistance to antibiotics has become a globally recognized public health problem. In most bacterial species, after exposing microorganisms to antibiotic peptides, several systems are affected such as energy and nitrogen metabolism regulation, glucan biosynthesis, amino acid, protein, and nucleotide synthesis, and, moreover, various proteins show a stress response. Despite some articles having been published about bacterial resistance toward antimicrobial peptides, multiple gaps need to be filled in order to better understand this mechanism. In this view, this edition proposes the analyses of these unusual and interesting peptides and will provide a clearer understanding of such bacterial resistance towards AMPs. In summary, this proposal focuses on AMPs and their multiple activities as well as on AMP bacterial resistance, attracting several researchers from different areas.
Titolo autorizzato: New edge of antibiotic development  Visualizza cluster
ISBN: 9782889193011
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910688234703321
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