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Autore: |
Giltrap Andrew
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Titolo: |
Total Synthesis of Natural Products with Antimicrobial Activity / / by Andrew Giltrap
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Pubblicazione: | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
Edizione: | 1st ed. 2018. |
Descrizione fisica: | 1 online resource (XXIV, 268 p. 144 illus., 59 illus. in color.) |
Disciplina: | 615.19 |
Soggetto topico: | Medicinal chemistry |
Medical biochemistry | |
Drug resistance | |
Medicinal Chemistry | |
Medical Biochemistry | |
Drug Resistance | |
Nota di contenuto: | Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental. |
Sommario/riassunto: | This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients. |
Titolo autorizzato: | Total Synthesis of Natural Products with Antimicrobial Activity ![]() |
ISBN: | 981-10-8806-3 |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910298585803321 |
Lo trovi qui: | Univ. Federico II |
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