Total Synthesis of Natural Products with Antimicrobial Activity / / by Andrew Giltrap

• Autore: Giltrap Andrew
• Pubblicazione: Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018
• Edizione: 1st ed. 2018.
• Descrizione fisica: 1 online resource (XXIV, 268 p. 144 illus., 59 illus. in color.)
• Disciplina: 615.19
• Soggetto topico: Medicinal chemistry; Medical biochemistry; Drug resistance; Medicinal Chemistry; Medical Biochemistry; Drug Resistance
• Nota di contenuto: Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.
• Sommario/riassunto: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
• Titolo autorizzato: Total Synthesis of Natural Products with Antimicrobial Activity
• ISBN: 981-10-8806-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910298585803321
• Lo trovi qui: Univ. Federico II
• Serie: Springer Theses, Recognizing Outstanding Ph.D. Research, . 2190-5053