03006nam 22005295 450 991029858580332120200702175556.0981-10-8806-310.1007/978-981-10-8806-3(CKB)4100000004244324(DE-He213)978-981-10-8806-3(MiAaPQ)EBC5379952(PPN)227399331(EXLCZ)99410000000424432420180502d2018 u| 0engurnn|008mamaatxtrdacontentcrdamediacrrdacarrierTotal Synthesis of Natural Products with Antimicrobial Activity /by Andrew Giltrap1st ed. 2018.Singapore :Springer Singapore :Imprint: Springer,2018.1 online resource (XXIV, 268 p. 144 illus., 59 illus. in color.) Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053981-10-8805-5 Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053Medicinal chemistryMedical biochemistryDrug resistanceMedicinal Chemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/C28000Medical Biochemistryhttps://scigraph.springernature.com/ontologies/product-market-codes/H35005Drug Resistancehttps://scigraph.springernature.com/ontologies/product-market-codes/B16020Medicinal chemistry.Medical biochemistry.Drug resistance.Medicinal Chemistry.Medical Biochemistry.Drug Resistance.615.19Giltrap Andrewauthttp://id.loc.gov/vocabulary/relators/aut768751BOOK9910298585803321Total Synthesis of Natural Products with Antimicrobial Activity1566586UNINA