Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs : Formulation Challenges and Potential Benefits

• Autore: Čalija Bojan
• Pubblicazione: San Diego : , : Elsevier Science & Technology, , 2017; ©2017
• Descrizione fisica: 1 online resource (286 pages)
• Disciplina: 615.1; 615.7
• Soggetto topico: Nonsteroidal anti-inflammatory agents; Drug carriers (Pharmacy)
• Altri autori: ČalijaBojan
• Nota di contenuto: Cover -- Title page -- Copyright page -- Contents -- List of Contributors -- Editor Biography -- Preface -- Chapter 1 - Clinical Uses of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Potential Benefits of NSAIDs Modified-Releas... -- 1.1 - Nonsteroidal Anti-inflammatory drugs -- 1.1.1 - Classification and Mechanism of Action -- 1.1.1.1 - Classification -- 1.1.1.2 - COX Isoforms and Their Roles -- 1.1.1.3 - NSAIDs Mechanism of Action -- 1.1.2 - Pharmacokinetic Properties -- 1.1.2.1 - Biopharmaceutical/Pharmacokinetic Considerations of Topically Administered NSAIDs -- 1.1.3 - Therapeutic Actions and Uses -- 1.1.3.1 - Musculoskeletal Disorders -- 1.1.3.1.1 - Osteoarthritis -- 1.1.3.1.2 - Rheumatoid Arthritis -- 1.1.3.2 - Mild to Moderate Pain -- 1.1.3.3 - Fever -- 1.1.3.4 - Cardioprotection (Aspirin) -- 1.1.4 - Adverse Effects -- 1.1.4.1 - Gastrointestinal Side Effects -- 1.1.4.2 - Cardiovascular Side Effects -- 1.1.4.3 - Renal Side Effects -- 1.1.5 - Interactions -- 1.2 - Potential benefits of NSAIDs modified-release preparations -- 1.2.1 - Oral NSAIDs Modified-Release Preparations -- 1.2.2 - Topical NSAIDs Modified-Release Preparations -- 1.3 - Conclusions -- Acknowledgment -- References -- Chapter 2 - Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Appl... -- 2.1 - Introduction -- 2.2 - Polymeric microparticles as drug carriers -- 2.2.1 - Microencapsulation Techniques -- 2.2.1.1 - Chemical Microencapsulation Techniques -- 2.2.1.2 - Physicochemical Microencapsulation Techniques -- 2.2.1.3 - Physicomechanical Microencapsulation Techniques -- 2.2.2 - Characteristics of Polymeric Microparticles -- 2.2.3 - Pharmaceutical Application of Polymeric Microparticles -- 2.3 - Porous inorganic materials as drug carriers -- 2.3.1 - Characteristics of Porous Inorganic Materials Used in Drug Delivery. ; 2.3.2 - Structured Porous Inorganic Materials Used in Drug Delivery: An Overview -- 2.3.3 - Pharmaceutical Application of Structured Porous Inorganic Materials -- 2.4 - Conclusions -- Acknowledgment -- References -- Chapter 3 - Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs -- 3.1 - Introduction -- 3.2 - Microemulsions and nanoemulsions as drug-delivery carriers -- 3.3 - Design and characterization of biocompatible microemulsion/nanoemulsion drug-delivery systems -- 3.4 - Evaluation of potential of microemulsion/nanoemulsion systems for oral delivery of NSAIDs -- 3.5 - Conclusions -- References -- Chapter 4 - Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers -- 4.1 - Introduction -- 4.2 - Functionality and performance of excipients: definitions and compendial status -- 4.3 - Biodegradable polymeric materials in micro/nanoparticles -- 4.3.1 - Definition, Structure, and Characteristics of Polymers -- 4.3.2 - Classification of Biodegradable Encapsulating Polymers -- 4.3.3 - The Selection of Encapsulating Polymer -- 4.3.4 - Functionality of Biodegradable Polymers as Excipients for Micro/Nanosized Drug Carriers -- 4.4 - Natural and synthetic silica-based materials as micro/nanosized drug carriers -- 4.4.1 - Structure and Functional Characteristics of Silica-Based Materials -- 4.4.2 - Functionalization of Natural and Synthetic Silica-Based Materials as Micro/Nanosized Drug Carriers -- 4.5 - Natural surfactants in micro/nanoemulsions -- 4.5.1 - Surfactant Role in Micro/Nanoemulsions -- 4.5.2 - Definition, Structure, and Classification of Natural Surfactants -- 4.5.3 - Functionality of Natural Surfactants as Excipients in Micro/Nanoemulsions -- 4.5.3.1 - Lecithin -- 4.5.3.2 - Sucrose Esters -- 4.5.3.3 - Alkyl Polyglucosides -- 4.6 - Conclusions -- Acknowledgment -- References. ; Chapter 5 - Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced Via Polyel... -- 5.1 - Introduction -- 5.2 - Chitosans: an overview on properties, functionality, and safety -- 5.2.1 - Source and Structural Characteristics of Chitosans -- 5.2.2 - Physicochemical Properties and Reactivity of Chitosans -- 5.2.3 - Safety and Regulatory Status of Chitosans -- 5.3 - Alginate-chitosan micro/nanoparticles as drug carriers -- 5.3.1 - Ca-Alginate Hydrogels as Drug Carriers: Characteristics and Disadvantages -- 5.3.2 - Chitosans as Cationic Modifiers of Ca-Alginate Micro/Nanoparticles -- 5.3.3 - Preparation Methods of Alginate-Chitosan Micro/Nanoparticles -- 5.4 - Influence of chitosans functional properties on characteristics of alginate-chitosan micro/nanoparticles loaded with ... -- 5.5 - Conclusions -- Acknowledgment -- References -- Chapter 6 - PLA-Based Nanoparticulate Drug Carriers as a Percutaneous Delivery System for Ketoprofen -- 6.1 - Introduction -- 6.2 - Ketoprofen-loaded PLA nanoparticles: preparation and characterization aspects -- 6.3 - In vitro evaluation of ketoprofen-loaded PLA nanoparticles as colloidal systems for percutaneous drug delivery -- 6.4 - Conclusions -- References -- Chapter 7 - Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs-Practical Formulation Approach, Physicochemical... -- 7.1 - Introduction -- 7.2 - Sucrose ester-based microemulsions: phase behavior, physicochemical characterization, and imaging properties -- 7.2.1 - Phase Behavior of Sucrose Ester-Based Systems -- 7.2.1.1 - Effect of the Tail Length of SEs -- 7.2.1.2 - Effect of Monoester Content of SEs -- 7.2.1.3 - Effect of Cosurfactant/Cosolvent Choice and Surfactant/Cosurfactant Weight Ratio -- 7.2.1.4 - Effect of HLB Values of SE. ; 7.2.2 - Physicochemical Properties of Sucrose Ester-Based Microemulsions -- 7.2.2.1 - Electrical Conductivity -- 7.2.2.2 - Viscosity -- 7.2.2.3 - Thermal Behavior -- 7.2.3 - Imaging Properties of Sucrose Ester-Based Microemulsions -- 7.2.3.1 - Cryo-Transmission Electron Microscopy -- 7.2.3.2 - Freeze Fracture-Transmission Electron Microscopy -- 7.2.3.3 - Atomic Force Microscopy -- 7.3 - Lecithin- and sucrose ester-based nanoemulsions-formulation design aspects, physicochemical characterization, and sta... -- 7.3.1 - The Selection of Emulsifiers-Lecithin and Sucrose Esters -- 7.3.2 - The Selection of Oil and Aqueous Phase -- 7.3.3 - Nanoemulsion Formulation and Preparation-QbD Approach -- 7.3.4 - Physicochemical Characterization and Stability Testing -- 7.3.4.1 - Droplet Size Analysis and Microstructure Evaluation -- 7.3.4.2 - Zeta Potential and pH Value Determination -- 7.3.4.3 - Viscosity Measurements -- 7.3.4.4 - Assessment of Drug Chemical Stability -- 7.4 - NSAID-loaded micro/nanoemulsions: in vitro/ex vivo/in vivo dermal and transdermal availability -- 7.5 - Conclusions -- Acknowledgment -- References -- Chapter 8 - Natural and Modified Silica-Based Materials as Carriers for NSAIDs -- 8.1 - Introduction -- 8.2 - Natural and modified aluminosilicates: characterization and application in drug delivery -- 8.2.1 - Physicochemical and Functionality-Related Characteristics of Natural and Modified Aluminosilicates: An Overview -- 8.2.2 - Natural and Modified Aluminosilicates: Application as Carriers for NSAIDs -- 8.3 - Modified biosilica structures from diatomite frustules: preparation, physicochemical characterization, and application -- 8.3.1 - Diatomite Processing and Its Physicochemical Characteristics -- 8.3.2 - Applications of Natural and Modified Diatomites in Drug Delivery -- 8.4 - Conclusions -- Acknowledgment -- References -- Index. ; Back cover.
• Titolo autorizzato: Microsized and nanosized carriers for nonsteroidal anti-inflammatory drugs
• ISBN: 0-12-804080-7; 0-12-804017-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910583323303321
• Lo trovi qui: Univ. Federico II