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[null,"1.","Record Nr.",null,"UNINA9910583323303321"]
[null,null,"Autore",null,"Čalija Bojan"]
[null,null,"Titolo",null,"Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs : Formulation Challenges and Potential Benefits"]
[null,null,"Pubbl/distr/stampa",null,"San Diego : , : Elsevier Science & Technology, , 2017"]
[{"$nulls":4},"©2017"]
[null,null,"ISBN",null,"0-12-804080-7"]
[{"$nulls":4},"0-12-804017-3"]
[null,null,"Descrizione fisica",null,"1 online resource (286 pages)"]
[null,null,"Disciplina",null,"615.1"]
[{"$nulls":4},"615.7"]
[null,null,"Soggetti",null,"Nonsteroidal anti-inflammatory agents"]
[{"$nulls":4},"Drug carriers (Pharmacy)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Title page -- Copyright page -- Contents -- List of Contributors -- Editor Biography -- Preface -- Chapter 1 - Clinical Uses of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Potential Benefits of NSAIDs Modified-Releas... -- 1.1 - Nonsteroidal Anti-inflammatory drugs -- 1.1.1 - Classification and Mechanism of Action -- 1.1.1.1 - Classification -- 1.1.1.2 - COX Isoforms and Their Roles -- 1.1.1.3 - NSAIDs Mechanism of Action -- 1.1.2 - Pharmacokinetic Properties -- 1.1.2.1 - Biopharmaceutical/Pharmacokinetic Considerations of Topically Administered NSAIDs -- 1.1.3 - Therapeutic Actions and Uses -- 1.1.3.1 - Musculoskeletal Disorders -- 1.1.3.1.1 - Osteoarthritis -- 1.1.3.1.2 - Rheumatoid Arthritis -- 1.1.3.2 - Mild to Moderate Pain -- 1.1.3.3 - Fever -- 1.1.3.4 - Cardioprotection (Aspirin) -- 1.1.4 - Adverse Effects -- 1.1.4.1 - Gastrointestinal Side Effects -- 1.1.4.2 - Cardiovascular Side Effects -- 1.1.4.3 - Renal Side Effects -- 1.1.5 - Interactions -- 1.2 - Potential benefits of NSAIDs modified-release preparations -- 1.2.1 - Oral NSAIDs Modified-Release Preparations -- 1.2.2 - Topical NSAIDs Modified-Release Preparations -- 1.3 - Conclusions -- Acknowledgment -- References -- Chapter 2 - Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Appl... -- 2.1 - Introduction -- 2.2 - Polymeric microparticles as drug carriers -- 2.2.1 - Microencapsulation "]
[{"$nulls":4},"Techniques -- 2.2.1.1 - Chemical Microencapsulation Techniques -- 2.2.1.2 - Physicochemical Microencapsulation Techniques -- 2.2.1.3 - Physicomechanical Microencapsulation Techniques -- 2.2.2 - Characteristics of Polymeric Microparticles -- 2.2.3 - Pharmaceutical Application of Polymeric Microparticles -- 2.3 - Porous inorganic materials as drug carriers -- 2.3.1 - Characteristics of Porous Inorganic Materials Used in Drug Delivery."]
[{"$nulls":4},"2.3.2 - Structured Porous Inorganic Materials Used in Drug Delivery: An Overview -- 2.3.3 - Pharmaceutical Application of Structured Porous Inorganic Materials -- 2.4 - Conclusions -- Acknowledgment -- References -- Chapter 3 - Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs -- 3.1 - Introduction -- 3.2 - Microemulsions and nanoemulsions as drug-delivery carriers -- 3.3 - Design and characterization of biocompatible microemulsion/nanoemulsion drug-delivery systems -- 3.4 - Evaluation of potential of microemulsion/nanoemulsion systems for oral delivery of NSAIDs -- 3.5 - Conclusions -- References -- Chapter 4 - Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers -- 4.1 - Introduction -- 4.2 - Functionality and performance of excipients: definitions and compendial status -- 4.3 - Biodegradable polymeric materials in micro/nanoparticles -- 4.3.1 - Definition, Structure, and Characteristics of Polymers -- 4.3.2 - Classification of Biodegradable Encapsulating Polymers -- 4.3.3 - The Selection of Encapsulating Polymer -- 4.3.4 - Functionality of Biodegradable Polymers as Excipients for Micro/Nanosized Drug Carriers -- 4.4 - Natural and synthetic silica-based materials as micro/nanosized drug carriers -- 4.4.1 - Structure and Functional Characteristics of Silica-Based Materials -- 4.4.2 - Functionalization of Natural and Synthetic Silica-Based Materials as Micro/Nanosized Drug Carriers -- 4.5 - Natural surfactants in micro/nanoemulsions -- 4.5.1 - Surfactant Role in Micro/Nanoemulsions -- 4.5.2 - Definition, Structure, and Classification of Natural Surfactants -- 4.5.3 - Functionality of Natural Surfactants as Excipients in Micro/Nanoemulsions -- 4.5.3.1 - Lecithin -- 4.5.3.2 - Sucrose Esters -- 4.5.3.3 - Alkyl Polyglucosides -- 4.6 - Conclusions -- Acknowledgment -- References."]
[{"$nulls":4},"Chapter 5 - Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced Via Polyel... -- 5.1 - Introduction -- 5.2 - Chitosans: an overview on properties, functionality, and safety -- 5.2.1 - Source and Structural Characteristics of Chitosans -- 5.2.2 - Physicochemical Properties and Reactivity of Chitosans -- 5.2.3 - Safety and Regulatory Status of Chitosans -- 5.3 - Alginate-chitosan micro/nanoparticles as drug carriers -- 5.3.1 - Ca-Alginate Hydrogels as Drug Carriers: Characteristics and Disadvantages -- 5.3.2 - Chitosans as Cationic Modifiers of Ca-Alginate Micro/Nanoparticles -- 5.3.3 - Preparation Methods of Alginate-Chitosan Micro/Nanoparticles -- 5.4 - Influence of chitosans functional properties on characteristics of alginate-chitosan micro/nanoparticles loaded with ... -- 5.5 - Conclusions -- Acknowledgment -- References -- Chapter 6 - PLA-Based Nanoparticulate Drug Carriers as a Percutaneous Delivery System for Ketoprofen -- 6.1 - Introduction -- 6.2 - Ketoprofen-loaded PLA nanoparticles: preparation and characterization aspects -- 6.3 - In vitro evaluation of ketoprofen-loaded PLA nanoparticles as colloidal systems for percutaneous drug delivery -- 6.4 - Conclusions -- References -- Chapter 7 - Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs-Practical Formulation Approach, Physicochemical... -- 7.1 - Introduction -- 7.2 - Sucrose ester-based microemulsions: phase behavior, physicochemical "]
[{"$nulls":4},"characterization, and imaging properties -- 7.2.1 - Phase Behavior of Sucrose Ester-Based Systems -- 7.2.1.1 - Effect of the Tail Length of SEs -- 7.2.1.2 - Effect of Monoester Content of SEs -- 7.2.1.3 - Effect of Cosurfactant/Cosolvent Choice and Surfactant/Cosurfactant Weight Ratio -- 7.2.1.4 - Effect of HLB Values of SE."]
[{"$nulls":4},"7.2.2 - Physicochemical Properties of Sucrose Ester-Based Microemulsions -- 7.2.2.1 - Electrical Conductivity -- 7.2.2.2 - Viscosity -- 7.2.2.3 - Thermal Behavior -- 7.2.3 - Imaging Properties of Sucrose Ester-Based Microemulsions -- 7.2.3.1 - Cryo-Transmission Electron Microscopy -- 7.2.3.2 - Freeze Fracture-Transmission Electron Microscopy -- 7.2.3.3 - Atomic Force Microscopy -- 7.3 - Lecithin- and sucrose ester-based nanoemulsions-formulation design aspects, physicochemical characterization, and sta... -- 7.3.1 - The Selection of Emulsifiers-Lecithin and Sucrose Esters -- 7.3.2 - The Selection of Oil and Aqueous Phase -- 7.3.3 - Nanoemulsion Formulation and Preparation-QbD Approach -- 7.3.4 - Physicochemical Characterization and Stability Testing -- 7.3.4.1 - Droplet Size Analysis and Microstructure Evaluation -- 7.3.4.2 - Zeta Potential and pH Value Determination -- 7.3.4.3 - Viscosity Measurements -- 7.3.4.4 - Assessment of Drug Chemical Stability -- 7.4 - NSAID-loaded micro/nanoemulsions: in vitro/ex vivo/in vivo dermal and transdermal availability -- 7.5 - Conclusions -- Acknowledgment -- References -- Chapter 8 - Natural and Modified Silica-Based Materials as Carriers for NSAIDs -- 8.1 - Introduction -- 8.2 - Natural and modified aluminosilicates: characterization and application in drug delivery -- 8.2.1 - Physicochemical and Functionality-Related Characteristics of Natural and Modified Aluminosilicates: An Overview -- 8.2.2 - Natural and Modified Aluminosilicates: Application as Carriers for NSAIDs -- 8.3 - Modified biosilica structures from diatomite frustules: preparation, physicochemical characterization, and application -- 8.3.1 - Diatomite Processing and Its Physicochemical Characteristics -- 8.3.2 - Applications of Natural and Modified Diatomites in Drug Delivery -- 8.4 - Conclusions -- Acknowledgment -- References -- Index."]
[{"$nulls":4},"Back cover."]
[null,null,null,"Sommario/riassunto","Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges and Potential Benefits provides a unique and complete overview of novel formulation strategies for improvement of the delivery of NSAIDs via encapsulation in microsized and nanosized carriers composed of different materials of natural and synthetic origin.This book presents the latest research on advances and limitations of both microsized and nanosized drug carriers and NSAIDs before discussing the formulation aspects of these drug carriers that are intended for oral, dermal, and transdermal administration of NSAIDs.In addition, functionality of these materials as potential excipients for microsized and nanosized carriers is discussed and debated. Practical solutions for improving effectiveness of these drugs are included throughout the book, making this an important resource for graduate students, professors, and researchers in the pharmaceutical sciences.- Covers a wide range of microsized and nanosized carriers in one resource, including particulate carriers (microparticles, nanoparticles, and zeolites) and the soft colloidal carriers, such as micro-emulsions and nano-emulsions- Presents the reader with various formulation approaches dependent on the characteristics of the material, model drug, and desired route of administration- Approaches are based on the latest research in the area and formulation strategies may have broader applications to the encapsulation of other active pharmaceutical ingredients"]