Cytochrome P450 2E1 : its role in disease and drug metabolism / / Aparajita Dey, editor
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| Titolo: |
Cytochrome P450 2E1 : its role in disease and drug metabolism / / Aparajita Dey, editor
|
| Pubblicazione: | New York, : Springer, 2013 |
| Edizione: | 1st ed. 2013. |
| Descrizione fisica: | 1 online resource (267 p.) |
| Disciplina: | 572.791 |
| Soggetto topico: | Cytochrome P-450 |
| Altri autori: |
DeyAparajita
|
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | Cytochrome P450 2E1 and its clinical aspects -- Nrf2 and antioxidant defense against CYP2E1 toxicity -- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis -- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome -- Relevance of CYP2E1 to non-alcoholic fatty liver disease -- CYP2E1-catalyzed alcohol metabolism -- CYP2E1, oxidative stress, post-translational modifications and lipid metabolism -- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. |
| Sommario/riassunto: | The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications. |
| Titolo autorizzato: | Cytochrome P450 2E1 |
| ISBN: | 1-299-40812-5 |
| 94-007-5881-2 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910737299003321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Subcellular Biochemistry, . 0306-0225 ; ; 67